ArticleJournal of the American Society for Mass Spectrometry2012
Deconstructing desorption electrospray ionization: independent optimization of desorption and ionization by spray desorption collection.
Article in Journal of the American Society for Mass Spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- An Absolute Quantitative Approach to Study the Desorption Step in Plasma-Based Ambient MS Methods.Analytical chemistry · 2026Article
- A statistical approach to system suitability testing for mass spectrometry imaging.Rapid communications in mass spectrometry : RCM · 2024Article
- Development and Application of Desorption Electrospray Ionization Mass Spectrometry for Historical Dye Analysis.Analytical chemistry · 2023Article
- PICA: Pixel Intensity Correlation Analysis for Deconvolution and Metabolite Identification in Mass Spectrometry Imaging.Analytical chemistry · 2023Article
- The application of mass spectrometry imaging in traditional Chinese medicine: a review.Chinese medicine · 2022Review
- Direct analysis of surface chemicals using vibrating sharp-edge spray ionization mass spectrometry.Rapid communications in mass spectrometry : RCM · 2020Article
- Systematic evaluation of repeatability of IR-MALDESI-MS and normalization strategies for correcting the analytical variation and improving image quality.Analytical and bioanalytical chemistry · 2019Article
- Addition of Serine Enhances Protein Analysis by DESI-MS.Journal of the American Society for Mass Spectrometry · 2019Article
- Ammonium Bicarbonate Addition Improves the Detection of Proteins by Desorption Electrospray Ionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2017Article
- Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques.Analytical chemistry · 2016Review
- Sample Preparation for Mass Spectrometry Imaging of Plant Tissues: A Review.Frontiers in plant science · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spray desorption collection (SDC) and reflective electrospray ionization (RESI) were used to independently study the desorption and ionization processes that together comprise desorption electrospray ionization (DESI). Both processes depend on several instrumental parameters, including the nebulizing gas flow rate, applied potential, and source geometries. Each of these parameters was optimized for desorption, as represented by the results obtained by SDC, and ionization, as represented by the results obtained by RESI. The optimized conditions were then compared to the optimization results for DESI. Our results confirm that optimal conditions for desorption and ionization are different and that in some cases the optimized DESI conditions are a compromise between both sets. The respective results for DESI, RESI, and SDC for each parameter were compared across the methods to draw conclusions about the contribution of each parameter to desorption and ionization separately and then combined within DESI. Our results indicate that desorption efficiency is (1) independent of the applied potential and (2) the impact zone to inlet distance, and that (3) gas pressure settings and (4) sprayer to impact zone distances above optimal for DESI are detrimental to desorption but beneficial for ionization. In addition, possible interpretations for the observed trends are presented.
Identifiers
22907171What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.