SynthesisEuropean archives of psychiatry and clinical neuroscience2013
Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence.
Synthesis in European archives of psychiatry and clinical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Magnetic resonance imaging-based machine learning classification of schizophrenia spectrum disorders: a meta-analysis.Psychiatry and clinical neurosciences · 2024Pooled it
- Cannabis use and psychosis: a review of reviews.European archives of psychiatry and clinical neuroscience · 2020Pooled it
- An etiological approach to psychosis: potential benefits for treatment, research and prevention.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Interaction of Cannabis Use Disorder and Striatal Connectivity in Antipsychotic Treatment Response.Schizophrenia bulletin open · 2020Article
- Neuroimaging Studies in Patients With Mental Disorder and Co-occurring Substance Use Disorder: Summary of Findings.Frontiers in psychiatry · 2019Review
- Impact of substance use disorder on gray matter volume in schizophrenia.Psychiatry research. Neuroimaging · 2018Article
- The Potential of Cannabidiol Treatment for Cannabis Users With Recent-Onset Psychosis.Schizophrenia bulletin · 2018Review
- Lower-Risk Cannabis Use Guidelines: A Comprehensive Update of Evidence and Recommendations.American journal of public health · 2017Review
- Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study.Schizophrenia bulletin · 2015Article
- Safety and Toxicology of Cannabinoids.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Brain volume in male patients with recent onset schizophrenia with and without cannabis use disorders.Journal of psychiatry & neuroscience : JPN · 2015Article
- Reduced hippocampal volume and hypothalamus-pituitary-adrenal axis function in first episode psychosis: evidence for sex differences.NeuroImage. Clinical · 2015Article
- Effects of eye dominance (left vs. right) and cannabis use on intermanual coordination and negative symptoms in schizophrenia patients.European archives of psychiatry and clinical neuroscience · 2014Article
- Cannabis-related working memory deficits and associated subcortical morphological differences in healthy individuals and schizophrenia subjects.Schizophrenia bulletin · 2014Article
- Pharmacological Interventions for the MATRICS Cognitive Domains in Schizophrenia: What's the Evidence?Frontiers in psychiatry · 2013Review
- Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia.European archives of psychiatry and clinical neuroscience · 2013Article
- Pathways from cannabis to psychosis: a review of the evidence.Frontiers in psychiatry · 2013Review
- Schizophrenia: brain morphology and treatment aspects.European archives of psychiatry and clinical neuroscience · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substance abuse is the most prevalent comorbid psychiatric condition associated with schizophrenia, and cannabis is the illicit drug most often abused. Apart from worsening the course of schizophrenia, frequent cannabis use especially at an early age seems to be an important risk factor for developing schizophrenia. Although a large body of neuroimaging studies gives evidence for structural alterations in many different brain regions in schizophrenia patients, there is still limited knowledge of the impact of cannabis abuse on brain structure in schizophrenia. We performed a systematic review including structural magnetic resonance imaging studies comparing high-risk and schizophrenia patients with and without cannabis abuse and found inconclusive results. While there is some evidence that chronic cannabis abuse could alter brain morphology in schizophrenia in patients continuing their cannabis consumption, there is no convincing evidence that this alteration takes place before the onset of schizophrenia when looking at first-episode patients. There is some weak evidence that cannabis abuse could affect brain structures in high-risk subjects, but replication of these studies is needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.