ArticleBrain : a journal of neurology2012
Nocturnal sleep enhances working memory training in Parkinson's disease but not Lewy body dementia.
Article in Brain : a journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Polysomnographic and Clinical Parameters before and after Zonisamide Therapy for Parkinson's Disease.Internal medicine (Tokyo, Japan) · 2023Trial
- Trial
- Competitive dynamics underlie cognitive improvements during sleep.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structural correlates of commission errors in prospective memory.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease.JAMA neurology · 2018Article
- Do Older Adults Need Sleep? A Review of Neuroimaging, Sleep, and Aging Studies.Current sleep medicine reports · 2017Article
- Rotigotine transdermal patch and sleep in Parkinson's disease: where are we now?NPJ Parkinson's disease · 2017Review
- Parkinson disease and cognitive impairment: Five new things.Neurology. Clinical practice · 2016Review
- Sleep, cognition, and normal aging: integrating a half century of multidisciplinary research.Perspectives on psychological science : a journal of the Association for Psychological Science · 2015Review
- The Interaction between Obstructive Sleep Apnea and Parkinson's Disease: Possible Mechanisms and Implications for Cognitive Function.Parkinson's disease · 2015Review
- Sleep correlates of trait executive function and memory in Parkinson's disease.Journal of Parkinson's disease · 2015Article
- Psychiatric issues in cognitive impairment.Movement disorders : official journal of the Movement Disorder Society · 2014Review
- The circadian regulation of sleep: impact of a functional ADA-polymorphism and its association to working memory improvements.PloS one · 2014Article
- Fluctuations in cognition and alertness vary independently in dementia with Lewy bodies.Movement disorders : official journal of the Movement Disorder Society · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Working memory is essential to higher order cognition (e.g. fluid intelligence) and to performance of daily activities. Though working memory capacity was traditionally thought to be inflexible, recent studies report that working memory capacity can be trained and that offline processes occurring during sleep may facilitate improvements in working memory performance. We utilized a 48-h in-laboratory protocol consisting of repeated digit span forward (short-term attention measure) and digit span backward (working memory measure) tests and overnight polysomnography to investigate the specific sleep-dependent processes that may facilitate working memory performance improvements in the synucleinopathies. We found that digit span backward performance improved following a nocturnal sleep interval in patients with Parkinson's disease on dopaminergic medication, but not in those not taking dopaminergic medication and not in patients with dementia with Lewy bodies. Furthermore, the improvements in patients with Parkinson's disease on dopaminergic medication were positively correlated with the amount of slow-wave sleep that patients obtained between training sessions and negatively correlated with severity of nocturnal oxygen desaturation. The translational implication is that working memory capacity is potentially modifiable in patients with Parkinson's disease but that sleep disturbances may first need to be corrected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.