Trial reportThe Journal of physiology2012
Dietary sodium loading impairs microvascular function independent of blood pressure in humans: role of oxidative stress.
Trial report in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04894344 (Education to Decrease in Sodium Intake in University Students Evaluated With 24 Hour Urinary Sodium Excretion), which is not on this map. Cited by 75 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Education to Decrease in Sodium Intake in University Students Evaluated With 24 Hour Urinary Sodium Excretion: Randomized Controlled Trial
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Effect of dietary salt restriction on central blood pressure: A systematic review and meta-analysis of the intervention studies.Journal of clinical hypertension (Greenwich, Conn.) · 2020Pooled it
- Chronobiology of meal timing in early-stage hypertension: a controlled feeding pilot study investigating the effects on renal and vascular function.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- The impact of dietary sodium and fructose on renal sodium handling and blood pressure in healthy adults.Physiological reports · 2025Trial
- Ten days of high dietary sodium does not impair cerebral blood flow regulation in healthy adults.Autonomic neuroscience : basic & clinical · 2021Trial
- Trial
- Antioxidant cocktail following a high-sodium meal does not affect vascular function in young, healthy adult humans: a randomized controlled crossover trial.Nutrition research (New York, N.Y.) · 2020Trial
- The Impact of High Dietary Sodium Consumption on Blood Pressure Variability in Healthy, Young Adults.American journal of hypertension · 2020Trial
- Salt Loading Blunts Central and Peripheral Postexercise Hypotension.Medicine and science in sports and exercise · 2020Trial
- Controlled Feeding of an 8-d, High-Dairy Cheese Diet Prevents Sodium-Induced Endothelial Dysfunction in the Cutaneous Microcirculation of Healthy, Older Adults through Reductions in Superoxide.The Journal of nutrition · 2020Trial
- Apocynin and Tempol ameliorate dietary sodium-induced declines in cutaneous microvascular function in salt-resistant humans.American journal of physiology. Heart and circulatory physiology · 2019Trial
- Reducing Dietary Sodium to 1000 mg per Day Reduces Neurovascular Transduction Without Stimulating Sympathetic Outflow.Hypertension (Dallas, Tex. : 1979) · 2019Trial
- Alterations in dietary sodium intake affect cardiovagal baroreflex sensitivity.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Trial
- Effects of vehicle microdialysis solutions on cutaneous vascular responses to local heating.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Central systolic blood pressure and aortic stiffness response to dietary sodium in young and middle-aged adults.Journal of the American Society of Hypertension : JASH · 2017Trial
- The role of cyclo-oxygenase-1 in high-salt diet-induced microvascular dysfunction in humans.The Journal of physiology · 2015Trial
- Salt loading has a more deleterious effect on flow-mediated dilation in salt-resistant men than women.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2014Trial
- Dietary salt, vascular dysfunction, and cognitive impairment.Cardiovascular research · 2025Review
- Hypothetical Behavioral Interventions for Mitigating the Cardiovascular Effects of Long-Term Fine Particulate Matter Exposure: Analyses From 2 Prospective Cohorts.Journal of the American Heart Association · 2025Article
- Salt-sensitive hypertension: role of endothelial and vascular dysfunction and sex.Frontiers in pharmacology · 2025Review
- Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high-salt diet.Acta physiologica (Oxford, England) · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Animal studies have reported dietary salt-induced reductions in vascular function independent of increases in blood pressure (BP). The purpose of this study was to determine if short-term dietary sodium loading impairs cutaneous microvascular function in normotensive adults with salt resistance. Following a control run-in diet, 12 normotensive adults (31 ± 2 years) were randomized to a 7 day low-sodium (LS; 20 mmol day(-1)) and 7 day high-sodium (HS; 350 mmol day(-1)) diet (controlled feeding study). Salt resistance, defined as a 5 mmHg change in 24 h mean BP determined while on the LS and HS diets, was confirmed in all subjects undergoing study (LS: 84 ± 1 mmHg vs. HS: 85 ± 2 mmHg; P > 0.05). On the last day of each diet, subjects were instrumented with two microdialysis fibres for the local delivery of Ringer solution and 20 mm ascorbic acid (AA). Laser Doppler flowmetry was used to measure red blood cell flux during local heating-induced vasodilatation (42°C). After the established plateau, 10 mm l-NAME was perfused to quantify NO-dependent vasodilatation. All data were expressed as a percentage of maximal cutaneous vascular conductance (CVC) at each site (28 mm sodium nitroprusside; 43°C). Sodium excretion increased during the HS diet (P < 0.05). The plateau % CVCmax was reduced during HS (LS: 93 ± 1 % CVCmax vs. HS: 80 ± 2 % CVCmax; P < 0.05). During the HS diet, AA improved the plateau % CVCmax (Ringer: 80 ± 2 % CVCmax vs. AA: 89 ± 3 % CVCmax; P < 0.05) and restored the NO contribution (Ringer: 44 ± 3 % CVCmax vs. AA: 59 ± 6 % CVCmax; P < 0.05). These data demonstrate that dietary sodium loading impairs cutaneous microvascular function independent of BP in normotensive adults and suggest a role for oxidative stress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.