ArticleThe Journal of physiology2012
Ageing and cardiorespiratory response to hypoxia.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial.Journal of translational medicine · 2021Trial
- Dose-response relationship of intermittent normobaric hypoxia to stimulate erythropoietin in the context of health promotion in young and old people.European journal of applied physiology · 2019Trial
- Inorganic nitrate supplementation attenuates peripheral chemoreflex sensitivity but does not improve cardiovagal baroreflex sensitivity in older adults.American journal of physiology. Heart and circulatory physiology · 2018Trial
- Proposal for defining the severity of environmental hypoxia.Frontiers in physiology · 2026Article
- Impact of menopause on responses to hypoxia and incidence of acute mountain sickness.European journal of applied physiology · 2025Article
- Article
- Women at Altitude: Sex-Related Physiological Responses to Exercise in Hypoxia.Sports medicine (Auckland, N.Z.) · 2024Review
- Age and estrogen-associated reductions in hypoxic ventilatory response and chemosensitivity in female rats.Frontiers in physiology · 2024Article
- PPARγ Agonist Pioglitazone Prevents Hypoxia-induced Cardiac Dysfunction by Reprogramming Glucose Metabolism.International journal of biological sciences · 2024Article
- Role of Vascular Receptors in the Development of Hypertension in the Elderly Population.The International journal of angiology : official publication of the International College of Angiology, Inc · 2022Article
- A Breathtaking Lift: Sex and Body Mass Index Differences in Cardiopulmonary Response in a Large Cohort of Unselected Subjects with Acute Exposure to High Altitude.High altitude medicine & biology · 2021Observational
- Impact of High Altitude on Cardiovascular Health: Current Perspectives.Vascular health and risk management · 2021Review
- Altitude and COVID-19: Friend or foe? A narrative review.Physiological reports · 2021Review
- Age-Dependent Association of Occult Hypoperfusion and Outcomes in Trauma.Journal of the American College of Surgeons · 2020Article
- Exercise Overrides Blunted Hypoxic Ventilatory Response in Prematurely Born Men.Frontiers in physiology · 2019Article
- Cerebrovascular Reactivity and Central Arterial Stiffness in Habitually Exercising Healthy Adults.Frontiers in physiology · 2018Article
- Limitation of Maximal Heart Rate in Hypoxia: Mechanisms and Clinical Importance.Frontiers in physiology · 2018Review
- Impaired peripheral vasodilation during graded systemic hypoxia in healthy older adults: role of the sympathoadrenal system.American journal of physiology. Heart and circulatory physiology · 2017Article
- The Influence of Age on Interaction between Breath-Holding Test and Single-Breath Carbon Dioxide Test.BioMed research international · 2017Article
- Lower hypoxic ventilatory response in smokers compared to non-smokers during abstinence from cigarettes.BMC pulmonary medicine · 2016Observational
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk of severe altitude-induced diseases is related to ventilatory and cardiac responses to hypoxia and is dependent on sex, age and exercise training status. However, it remains unclear how ageing modifies these physiological adaptations to hypoxia. We assessed the physiological responses to hypoxia with ageing through a cross-sectional 20 year study including 4675 subjects (2789 men, 1886 women; 14-85 years old) and a longitudinal study including 30 subjects explored at a mean 10.4 year interval. The influence of sex, training status and menopause was evaluated. The hypoxia-induced desaturation and the ventilatory and cardiac responses to hypoxia at rest and exercise were measured. In men, ventilatory response to hypoxia increased (P < 0.002), while desaturation was less pronounced (P < 0.001) with ageing. Cardiac response to hypoxia was blunted with ageing in both sexes (P < 0.001). Similar results were found in the longitudinal study, with a decrease in cardiac and an increase in ventilatory response to hypoxia with ageing. These adaptive responses were less pronounced or absent in post-menopausal women (P < 0.01). At exercise, desaturation was greater in trained subjects but cardiac and ventilatory responses to hypoxia were preserved by training, especially in elderly people. In conclusion, respiratory response to hypoxia and blood oxygenation improve with ageing in men while cardiac response is blunted with ageing in both sexes. Training aggravates desaturation at exercise in hypoxia, improves the ventilatory response and limits the ageing-induced blunting of cardiac response to hypoxia. Training limits the negative effects of menopause in cardiorespiratory adaptations to hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.