Evidence map›Paper›PMID 22906931›Full record

ReviewHuman vaccines & immunotherapeutics2012

Immune reconstitution and vaccination outcome in HIV-1 infected children: present knowledge and future directions.

Alberto Cagigi, Nicola Cotugno, Carlo Giaquinto, Luciana Nicolosi, Stefania Bernardi, Paolo Rossi, Iyadh Douagi, Paolo Palma

Open access · bronzeAbstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Artificial Intelligence Applied toFrontiers in immunology · 2020
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Induction ofJournal of immunology (Baltimore, Md. : 1950) · 2017
    Article
  18. Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Alberto CagigiUniversity Department of Pediatrics, Unit of Immunology and Infectious Diseases, Children's Hospital Bambino Gesù, Rome, Italy.
Nicola Cotugno
Carlo Giaquinto
Luciana Nicolosi
Stefania Bernardi
Paolo Rossi
Iyadh Douagi
Paolo Palma
Bambino Gesù Children's Hospital · ITBoston Children's Hospital · USKarolinska Institutet · SEPediatrics and Genetics · USUniversity of Padua · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current evidence on routine immunization of HIV-1 infected children point out the need for a special vaccine schedule in this population. However, optimal strategies for identifying individuals susceptible to infections, and then offering them sustained protection through appropriate immunization schedule, both in terms of timing and number of vaccine doses, still remain to be elucidated. Understanding the degree of immune recovery after HAART initiation is important in guiding administration of routine vaccination in HIV-1 infected children. Although quantitative measures (e.g., CD4+ T-cell counts and immunoglobulin levels) are frequently performed to evaluate immune parameters, these measures do not fully mirror functional immune recovery. Here, we will review the status of single mandatory and recommended vaccines for HIV-1 infected children in relation to immune recovery after HAART initiation with the aim of identifying new means to help design personalized vaccine schedules for this population.

Indexed as

Anti-HIV AgentsAntiretroviral Therapy, Highly ActiveChildHIV-1HIV InfectionsHumansImmunization SchedulePrecision MedicineTreatment OutcomeVaccinationVaccinesAnti-HIV AgentsVaccinesAIDSHAARTimmunization scheduleprotective immune responsesvertical infection

Identifiers

PMID22906931
PMCPMC3656066
OpenAlexW2021931474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.