ReviewMolecular and biochemical parasitology2012
Sirtuins of parasitic protozoa: in search of function(s).
Review in Molecular and biochemical parasitology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Molecular characterization and protective efficacy of silent information regulator 2A from Eimeria tenella.Parasites & vectors · 2016Trial
- Toxoplasma gondii SIR2A Promotes Tachyzoite Invasion via Lysine Deacetylase Activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum.Malaria journal · 2024Review
- Synthesis andFrontiers in chemistry · 2024Article
- Telomere maintenance in African trypanosomes.Frontiers in molecular biosciences · 2023Review
- Virtual Screening in the Identification of Sirtuins' Activity Modulators.Molecules (Basel, Switzerland) · 2022Review
- Involvement of ectonucleotidases and purinergic receptor expression during acute Chagas disease in the cortex of mice treated with resveratrol and benznidazole.Purinergic signalling · 2021Article
- The role of the Acanthamoeba castellanii Sir2-like protein in the growth and encystation of Acanthamoeba.Parasites & vectors · 2020Article
- Identification of Inhibitors toInternational journal of molecular sciences · 2020Article
- Novel Synthetic Approaches for Bisnaphthalimidopropyl (BNIP) Derivatives as Potential Anti-Parasitic Agents for the Treatment of Leishmaniasis.Molecules (Basel, Switzerland) · 2019Article
- Chemical Constituents ofMolecules (Basel, Switzerland) · 2019Article
- GlSir2.1 ofHeliyon · 2019Article
- Pumilacidins from the Octocoral-AssociatedMolecules (Basel, Switzerland) · 2018Article
- Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis.GigaScience · 2018Article
- Article
- Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.PLoS neglected tropical diseases · 2018Article
- The mitochondrial SIR2 related protein 2 (SIR2RP2) impacts Leishmania donovani growth and infectivity.PLoS neglected tropical diseases · 2017Article
- Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.Scientific reports · 2016Article
- In-silico screening of Schistosoma mansoni Sirtuin1 inhibitors for prioritization of drug candidates.SpringerPlus · 2016Article
- Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals.PLoS neglected tropical diseases · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The SIR2 family of NAD(+)-dependent protein deacetylases, collectively called sirtuins, has been of central interest due to their proposed roles in life-span regulation and ageing. Sirtuins are one group of environment sensors of a cell interpreting external information and orchestrating internal responses at the sub-cellular level, through participation in gene regulation mechanisms. Remarkably conserved across all kingdoms of life SIR2 proteins in several protozoan parasites appear to have both conserved and intriguing unique functions. This review summarises our current knowledge of the members of the sirtuin families in Apicomplexa, including Plasmodium, and other protozoan parasites such as Trypanosoma and Leishmania. The wide diversity of processes regulated by SIR2 proteins makes them targets worthy of exploitation in anti-parasitic therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.