Evidence map›Paper›PMID 22906340›Full record

ArticleJSLS : Journal of the Society of Laparoendoscopic Surgeons

Surgical management of neurovascular bundle in uterine fibroid pseudocapsule.

Andrea Tinelli, Antonio Malvasi, Brad S Hurst, Daniel A Tsin, Fausto Davila, Guillermo Dominguez, Domenico Dell'edera, Carlo Cavallotti, Roberto Negro, Sarah Gustapane and 2 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in JSLS : Journal of the Society of Laparoendoscopic Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06474065 (Pregnancy Outcomes Following Hysteroscopic, Laparoscopic and Laparotomic Myomectomy), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06474065 completednot on this map

Pregnancy Outcomes Following Hysteroscopic, Laparoscopic and Laparotomic Myomectomy

Typeobservational_patient_registrySponsorCentro di Ricerca Clinica SalentinoRan2024 to 2025Enrolled150ConditionsUterine Fibroid, Pregnancy Complications, Reproductive Issues, Reproductive SterilityArmsMyomectomy
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Uterine smooth muscle tumors with uncertain malignant potential: analysis following fertility-saving procedures.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023
    Article
  10. Review
  11. Review
  12. Observational
  13. Article
  14. Myomas and Adenomyosis: Impact on Reproductive Outcome.BioMed research international · 2017
    Review
  15. Robotic surgery in gynecology.Journal of minimal access surgery
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 4 countries.

Andrea TinelliDepartment of Obstetrics and Gynaecology, Vito Fazzi Hospital, Lecce, Italy. andreatinelli@gmail.com
Antonio Malvasi
Brad S Hurst
Daniel A Tsin
Fausto Davila
Guillermo Dominguez
Domenico Dell'edera
Carlo Cavallotti
Roberto Negro
Sarah Gustapane
Chris M Teigland
Liselotte Mettler
Ospedale Vito Fazzi · ITFundación para la Investigación, Docencia y Prevención del Cáncer · ARMount Sinai Hospital · USOspedale Madonna Delle Grazie · ITOspedale SS. Annunziata · ITSanta Maria Nuova Hospital · ITSapienza University of Rome · ITUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The uterine fibroid pseudocapsule is a fibro-neurovascular structure surrounding a leiomyoma, separating it from normal peripheral myometrium. The fibroid pseudocapsule is composed of a neurovascular network rich in neurofibers similar to the neurovascular bundle surrounding a prostate. The nerve-sparing radical prostatectomy has several intriguing parallels to myomectomy. It may serve either as a useful model in modern fibroid surgical removal, or it may accelerate our understanding of the role of the fibrovascular bundle and neurotransmitters in the healing and restoration of reproductive potential after intracapsular myomectomy. Surgical innovations, such as laparoscopic or robotic myomectomy applied to the intracapsular technique with magnification of the fibroid pseudocapsule surrounding a leiomyoma, originated from the radical prostatectomy method that highlighted a careful dissection of the neurovascular bundle to preserve sexual functioning after prostatectomy. Gentle uterine leiomyoma detachment from the pseudocapsule neurovascular bundle has allowed a reduction in uterine bleeding and uterine musculature trauma with sparing of the pseudocapsule neuropeptide fibers. This technique has had a favorable impact on functionality in reproduction and has improved fertility outcomes. Further research should determine the role of the myoma pseudocapsule neurovascular bundle in the formation, growth, and pathophysiological consequences of fibroids, including pain, infertility, and reproductive outcomes.

Indexed as

FemaleGynecologic Surgical ProceduresHumansLeiomyomaMaleMicrosurgeryMyometriumProstatectomyProstatic NeoplasmsUltrasonographyUterine NeoplasmsUterus

Identifiers

PMID22906340
PMCPMC3407432
OpenAlexW1980109547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.