ArticleBreast cancer research : BCR2012
Gene-expression profiling of microdissected breast cancer microvasculature identifies distinct tumor vascular subtypes.
Article in Breast cancer research : BCR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Meta-Analysis of Microdissected Breast Tumors Reveals Genes Regulated in the Stroma but Hidden in Bulk Analysis.Cancers · 2021Article
- Dynamic Contrast Enhanced MRI and Intravoxel Incoherent Motion to Identify Molecular Subtypes of Breast Cancer with Different Vascular Normalization Gene Expression.Korean journal of radiology · 2021Article
- Identification of disease-promoting stromal components by comparative proteomic and transcriptomic profiling of canine mammary tumors using laser-capture microdissected FFPE tissue.Neoplasia (New York, N.Y.) · 2021Article
- Characterization of Tumor Blood Vasculature Expression of Human Invasive Bladder Cancer by Laser Capture Microdissection and Transcriptional Profiling.The American journal of pathology · 2020Article
- Study of Gene Expression Profiles of Breast Cancers in Indian Women.Scientific reports · 2019Article
- Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β-induced Serpine1.The Journal of clinical investigation · 2019Article
- Alternative transcription of a shorter, non-anti-angiogenic thrombospondin-2 variant in cancer-associated blood vessels.Oncogene · 2018Article
- Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells.Oncotarget · 2018Article
- Animal models for studying tumor microenvironment (TME) and resistance to lymphocytic infiltration.Cancer biology & therapy · 2018Review
- Interactions between the tumor and the blood systemic response of breast cancer patients.PLoS computational biology · 2017Article
- Analysis of Gene Expression Signatures in Cancer-Associated Stroma from Canine Mammary Tumours Reveals Molecular Homology to Human Breast Carcinomas.International journal of molecular sciences · 2017Article
- Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy.JCI insight · 2016Article
- The novel VEGF receptor 2 inhibitor YLL545 inhibits angiogenesis and growth in breast cancer.Oncotarget · 2016Article
- Anti-angiogenic alternatives to VEGF blockade.Clinical & experimental metastasis · 2016Review
- Anti-vascular endothelial growth factor therapy in breast cancer.International journal of molecular sciences · 2014Review
- Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis.Clinical & experimental metastasis · 2014Article
- Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness.Molecular & cellular proteomics : MCP · 2013Article
- Biomarkers for anti-angiogenic therapy in cancer.International journal of molecular sciences · 2013Review
- ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties.PloS one · 2010Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
introductionAngiogenesis represents a potential therapeutic target in breast cancer. However, responses to targeted antiangiogenic therapies have been reported to vary among patients. This suggests that the tumor vasculature may be heterogeneous and that an appropriate choice of treatment would require an understanding of these differences.
methodsTo investigate whether and how the breast tumor vasculature varies between individuals, we isolated tumor-associated and matched normal vasculature from 17 breast carcinomas by laser-capture microdissection, and generated gene-expression profiles. Because microvessel density has previously been associated with disease course, tumors with low (n = 9) or high (n = 8) microvessel density were selected for analysis to maximize heterogeneity for this feature.
resultsWe identified differences between tumor and normal vasculature, and we describe two subtypes present within tumor vasculature. These subtypes exhibit distinct gene-expression signatures that reflect features including hallmarks of vessel maturity. Potential therapeutic targets (MET, ITGAV, and PDGFRβ) are differentially expressed between subtypes. Taking these subtypes into account has allowed us to derive a vascular signature associated with disease outcome.
conclusionsOur results further support a role for tumor microvasculature in determining disease progression. Overall, this study provides a deeper molecular understanding of the heterogeneity existing within the breast tumor vasculature and opens new avenues toward the improved design and targeting of antiangiogenic therapies.
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