ArticlePediatric transplantation2012
Changes in biomarkers of bone resorption over the first six months after pediatric hematopoietic cell transplantation.
Article in Pediatric transplantation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02074631 (Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation
Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Bone mineral density in children with fanconi anemia after hematopoietic cell transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2015Trial
- Bone loss and vitamin D deficiency in children undergoing hematopoietic cell transplantation.Pediatric blood & cancer · 2015Trial
- Body Composition, Bone Health, and Dietary Intake in Children After Allogeneic Hematopoietic Stem Cell Transplantation.Nutrients · 2026Observational
- Bone Turnover Marker for the Evaluation of Skeletal Remodelling in Autosomal Recessive Osteopetrosis after Haematopoietic Stem Cell Transplantation: A Case Report.Children (Basel, Switzerland) · 2023Article
- Endocrine disorders in Fanconi anemia: recommendations for screening and treatment.The Journal of clinical endocrinology and metabolism · 2015Review
- Bone mineral deficits in recipients of hematopoietic cell transplantation: the impact of young age at transplant.Bone marrow transplantation · 2014Article
- Biomarkers of bone remodeling in children with mucopolysaccharidosis types I, II, and VI.Journal of pediatric rehabilitation medicine · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Bone loss has been observed within the first six months after HCT in both children and adults. While there is some evidence that bone formation may be reduced in children after HCT, it is currently unknown whether bone resorption is increased. The objective of this prospective study was to evaluate changes in markers of bone resorption over the first six months after pediatric HCT. Twenty-six participants (eight females) aged 10.9 ± 3.4 yr entered the study prior to HCT. Bone resorption was measured by urine DPD and PYD, and by plasma NTX and CTX. Seventeen participants who completed day +30 visit and either day +100 or +180 visits were included in the analysis. DPD increased between days +30 and +100 (mean change, 11.3 nmol/nmol creatinine; p = 0.012) and between days +30 and +180 (13.7 nmol/nmol creatinine; p = 0.036). PYD increased between days +30 and +100 (32 nmBCE/L; p = 0.019). CTX increased between baseline and day +100 (5.9 μg/L; p = 0.012). Changes in NTX levels were not statistically significant. This study shows that markers of bone resorption increase in children after HCT, suggesting that increased resorption may be a contributing factor to the pathophysiology of bone loss after pediatric HCT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.