ArticleBehavioral neuroscience2012
Chronic stress impairs prefrontal cortex-dependent response inhibition and spatial working memory.
Article in Behavioral neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 103 citations in OpenAlex.
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- Self-Regulation Mediates the Relationship Between Stress and Quality of Life in Shift-Working Healthcare Professionals: Behavioral Clustering Insights.European journal of investigation in health, psychology and education · 2025Article
- Prospective Memory Performance of Autistic Adults in Everyday Life: The Role of Stress and Motivation.Autism research : official journal of the International Society for Autism Research · 2025Article
- Executive functioning is linked to feeding practices and food insecurity in Head Start mothers.Appetite · 2025Article
- Left OFC Activation in Functional Near-Infrared Spectroscopy during an Inhibitory Control Task in an Early Years Sample: Integrating Stress Responses with Cognitive Function and Brain Activation.Developmental neuroscience · 2025Article
- Environmental enrichment reverses prenatal ethanol exposure-induced attention-deficits in rats.Frontiers in psychiatry · 2025Article
- Cognitive Health Costs of Poor Housing for Women: Exploring Executive Function and Housing Stress in Urban Slums in India.International journal of environmental research and public health · 2024Article
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- Restraint stress-induced effects on learning, memory, cognition, and expression of transcripts in different brain regions of mice.Molecular biology reports · 2024Article
- The Insidious Influence of Stress: An Integrated Model of Stress, Executive Control, and Psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Trigeminal Stimulation and Visuospatial Performance: The Struggle between Chewing and Trigeminal Asymmetries.Biomedicines · 2023Article
- Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats.Neuroscience and biobehavioral reviews · 2023Review
- The role of attention control in complex real-world tasks.Psychonomic bulletin & review · 2022Review
- Encore: Behavioural animal models of stress, depression and mood disorders.Frontiers in behavioral neuroscience · 2022Review
- A Mini-Review of Work Stress and Mindfulness: A Neuropsychological Point of View.Frontiers in psychology · 2022Review
- Associations between social burden, perceived stress, and diurnal cortisol profiles in older adults: implications for cognitive aging.European journal of ageing · 2021Article
- The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction.Molecular psychiatry · 2021Article
- Dorsolateral prefrontal cortex response to negative tweets relates to executive functioning.Social cognitive and affective neuroscience · 2020Article
- Hippocampus and cognitive domain deficits in treatment-resistant schizophrenia: A comparison with matched treatment-responsive patients and healthy controlsPsychiatry research. Neuroimaging · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Chronic stress leads to neurochemical and structural alterations in the prefrontal cortex (PFC) that correspond to deficits in PFC-mediated behaviors. The present study examined the effects of chronic restraint stress on response inhibition (using a response-withholding task, the fixed-minimum interval schedule of reinforcement, or FMI), and working memory (using a radial arm water maze, RAWM). Adult male Sprague-Dawley rats were first trained on the RAWM and subsequently trained on FMI. After acquisition of FMI, rats were assigned to a restraint stress (6h/d/28d in wire mesh restrainers) or control condition. Immediately after chronic stress, rats were tested on FMI and subsequently on RAWM. FMI results suggest that chronic stress reduces response inhibition capacity and motivation to initiate the task on selective conditions when sucrose reward was not obtained on the preceding trial. RAWM results suggest that chronic stress produces transient deficits in working memory without altering previously consolidated reference memory. Behavioral measures from FMI failed to correlate with metrics from RAWM except for one in which changes in FMI timing imprecision negatively correlated with changes in RAWM working memory errors for the controls, a finding that was not observed following chronic stress. Fisher's r-to-z transformation revealed no significant differences between control and stress groups with correlation coefficients. These findings are the first to show that chronic stress impairs both response inhibition and working memory, two behaviors that have never been directly compared within the same animals after chronic stress, using FMI, an appetitive task, and RAWM, a nonappetitive task.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.