ArticleBMC infectious diseases2012
Detection of IS6110 and HupB gene sequences of Mycobacterium tuberculosis and bovis in the aortic tissue of patients with Takayasu's arteritis.
Article in BMC infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Prevalence of tuberculosis infection among patients with Takayasu arteritis: a meta-analysis of observational studies.Scientific reports · 2023Pooled it
- Association between Takayasu arteritis and latent or active Mycobacterium tuberculosis infection: a systematic review.Clinical rheumatology · 2020Pooled it
- Posterior Reversible Encephalopathy Syndrome in a Young Female with Takayasu and Tubercular Arteritis: A Rare Case Report.Annals of African medicine · 2026Article
- Rapid detection of Mycobacterium tuberculosis based on cyp141 via real-time fluorescence loop-mediated isothermal amplification (cyp141-RealAmp).Frontiers in cellular and infection microbiology · 2024Article
- Tuberculosis and Takayasu arteritis: a case report.Journal of medical case reports · 2023Article
- Cardiovascular Involvement in Tuberculosis: From Pathophysiology to Diagnosis and Complications-A Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
- Complex Case of Tuberculosis Lymphadenitis with Concurrent Takayasu Arteritis in a 14-Year-Old Girl from Ethiopia.Open access rheumatology : research and reviews · 2023Article
- High prevalence of latent tuberculosis using the QuantiFERON-TB Gold Plus test in Takayasu arteritis.Archives of rheumatology · 2022Article
- Stroke in Takayasu arteritis with concomitant tuberculosis: an unusual pediatric case report.BMC pediatrics · 2022Article
- Transcriptome profiling of abdominal aortic tissues reveals alterations in mRNAs of Takayasu arteritis.Frontiers in genetics · 2022Article
- Offense and Defense in Granulomatous Inflammation Disease.Frontiers in cellular and infection microbiology · 2022Review
- Takayasu's Arteritis and Its Association With Mycobacterium Tuberculosis: A Systematic Review.Cureus · 2021Review
- Pathogens in Vasculitis: Is It Really Idiopathic?JMA journal · 2021Review
- Pathogenesis of liver injury in Takayasu arteritis: advanced understanding leads to new horizons.The Journal of international medical research · 2020Article
- Is Takayasu arteritis the result of a Mycobacterium tuberculosis infection? The use of TNF inhibitors may be the proof-of-concept to demonstrate that this association is epiphenomenal.Clinical rheumatology · 2020Review
- Childhood-onset Takayasu Arteritis.European journal of rheumatology · 2020Article
- Lack of Association between Cytokine Genetic Polymorphisms in Takayasu's Arteritis in Mexican Patients.International journal of environmental research and public health · 2019Article
- Tuberculosis in Takayasu arteritis: a retrospective study in 1105 Chinese patients.Journal of geriatric cardiology : JGC · 2019Article
- Sex Differences in Pediatric Rheumatology.Clinical reviews in allergy & immunology · 2019Review
- Childhood-Onset Takayasu Arteritis (c-TA): Current and Future Drug Therapy.Paediatric drugs · 2019Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTakayasu's arteritis (TA) is a chronic inflammatory disease affecting the large arteries and their branches; its etiology is still unknown. In individuals suffering from TA, arterial inflammation progresses to stenosis and/or occlusion, leading to organ damage and affecting survival. Relation of TA with Mycobacterium tuberculosis has been known, but there have been only a few systematic studies focusing on this association. The IS6110 sequence identifies the Mycobacterium tuberculosis complex and the HupB establishes the differences between M. tuberculosis and M. bovis. Our objective was to search the presence of IS6110 and HupB genes in aorta of patients with TA.
methodsWe analyzed aorta tissues embedded in paraffin from 5760 autopsies obtained from our institution, we divided the selected samples as cases and controls; CASES: aortic tissues of individuals with Takayasu's arteritis. Control positive: aortic tissues (with tuberculosis disease confirmed) and control negative with other disease aortic (atherosclerosis).
resultsOf 181 selected aorta tissues, 119 fulfilled the corresponding criteria for TA, TB or atherosclerosis. Thus 33 corresponded to TA, 33 to tuberculosis (TB) and 53 to atherosclerosis. The mean age was 22 ± 13, 41 ± 19, and 57 ± 10, respectively. IS6110 and HupB sequences were detected in 70% of TA tissues, 82% in tuberculosis, and in 32% with atherosclerosis. Important statistical differences between groups with TA, tuberculosis versus atherosclerosis (p = 0.004 and 0.0001, respectively) were found.
conclusionWe identified a higher frequency of IS6110 and HupB genes in aortic tissues of TA patients. This data suggests that arterial damage could occur due to previous infection with M. tuberculosis.
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