ArticleJournal of evolutionary biology2012
Variation in infectivity and aggressiveness in space and time in wild host-pathogen systems: causes and consequences.
Article in Journal of evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed.
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- Spatial scale break in ecological strategies for host use by plant viruses.Frontiers in microbiology · 2026Article
- Synthesizing selection mosaic theory and host-pathogen theory to explain large-scale pathogen coexistence.Nature communications · 2025Article
- High-resolution profiling of bacterial and fungal communities using pangenome-informed taxon-specific long-read amplicons.Microbiome · 2025Article
- Mechanistic models to meet the challenge of climate change in plant-pathogen systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Natural Flora Is Indiscriminately Hosting High Loads of Generalist Fungal PathogenJournal of fungi (Basel, Switzerland) · 2023Article
- A diverse parasite pool can improve effectiveness of biological control constrained by genotype-by-genotype interactions.Evolutionary applications · 2022Article
- Coinfection with a virus constrains within-host infection load but increases transmission potential of a highly virulent fungal plant pathogen.Ecology and evolution · 2022Article
- A Study of the Coevolution of Digital Organisms with an Evolutionary Cellular Automaton.Biology · 2021Article
- Population-level deep sequencing reveals the interplay of clonal and sexual reproduction in the fungal wheat pathogenMicrobial genomics · 2021Article
- The roles of environmental variation and parasite survival in virulence-transmission relationships.Royal Society open science · 2021Review
- Effect of maternal infection on progeny growth and resistance mediated by maternal genotype and nutrient availability.The Journal of ecology · 2021Article
- Maintenance of variation in virulence and reproduction in populations of an agricultural plant pathogen.Evolutionary applications · 2021Article
- Genetic analysis reveals long-standing population differentiation and high diversity in the rust pathogen Melampsora lini.PLoS pathogens · 2020Article
- Contrasting the seasonal and elevational prevalence of generalist avian haemosporidia in co-occurring host species.Ecology and evolution · 2020Article
- Genomics of sorghum local adaptation to a parasitic plant.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Variation and correlations between sexual, asexual and natural enemy resistance life-history traits in a natural plant pathogen population.BMC evolutionary biology · 2019Article
- Evidence of within-species specialization by soil microbes and the implications for plant community diversity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Sympatric versus allopatric evolutionary contexts shape differential immune response in Biomphalaria / Schistosoma interaction.PLoS pathogens · 2019Article
Corrections and comments
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5 authors.
Funding
Abstract
Variation in host resistance and in the ability of pathogens to infect and grow (i.e. pathogenicity) is important as it provides the raw material for antagonistic (co)evolution and therefore underlies risks of disease spread, disease evolution and host shifts. Moreover, the distribution of this variation in space and time may inform us about the mode of coevolutionary selection (arms race vs. fluctuating selection dynamics) and the relative roles of G × G interactions, gene flow, selection and genetic drift in shaping coevolutionary processes. Although variation in host resistance has recently been reviewed, little is known about overall patterns in the frequency and scale of variation in pathogenicity, particularly in natural systems. Using 48 studies from 30 distinct host-pathogen systems, this review demonstrates that variation in pathogenicity is ubiquitous across multiple spatial and temporal scales. Quantitative analysis of a subset of extensively studied plant-pathogen systems shows that the magnitude of within-population variation in pathogenicity is large relative to among-population variation and that the distribution of pathogenicity partly mirrors the distribution of host resistance. At least part of the variation in pathogenicity found at a given spatial scale is adaptive, as evidenced by studies that have examined local adaptation at scales ranging from single hosts through metapopulations to entire continents and - to a lesser extent - by comparisons of pathogenicity with neutral genetic variation. Together, these results support coevolutionary selection through fluctuating selection dynamics. We end by outlining several promising directions for future research.
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