ArticleExperimental lung research2012
Mechanostructural adaptations preceding postpneumonectomy lung growth.
Article in Experimental lung research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- MiR-155 promotes compensatory lung growth by inhibiting JARID2 activation of CD34+ endothelial progenitor cells.PloS one · 2024Article
- Intussusceptive angiogenesis and its counterpart intussusceptive lymphangiogenesis.Histology and histopathology · 2020Review
- Structural heteropolysaccharides as air-tight sealants of the human pleura.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Vascular endothelial growth factor accelerates compensatory lung growth by increasing the alveolar units.Pediatric research · 2018Article
- Functional Mechanics of a Pectin-Based Pleural Sealant after Lung Injury.Tissue engineering. Part A · 2018Article
- Pressure-decay testing of pleural air leaks in intact murine lungs: evidence for peripheral airway regulation.Physiological reports · 2018Article
- The puzzling mechanism of compensatory lung growth.Stem cell investigation · 2018Article
- Evidence for pleural epithelial-mesenchymal transition in murine compensatory lung growth.PloS one · 2017Article
- Deformation-induced transitional myofibroblasts contribute to compensatory lung growth.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Localization and stretch-dependence of lung elastase activity in development and compensatory growth.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Computational analysis of lung deformation after murine pneumonectomy. [corrected].Computer methods in biomechanics and biomedical engineering · 2014Article
- Mapping cyclic stretch in the postpneumonectomy murine lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Effect of unilateral diaphragmatic paralysis on postpneumonectomy lung growth.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Migration of CD11b+ accessory cells during murine lung regeneration.Stem cell research · 2013Article
- Detection of murine post-pneumonectomy lung regeneration by 18FDG PET imaging.EJNMMI research · 2012Article
- Structural and functional evidence for the scaffolding effect of alveolar blood vessels.Experimental lung researchArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
In many species, pneumonectomy results in compensatory growth in the remaining lung. Although the late mechanical consequences of murine pneumonectomy are known, little is known about the anatomic adaptations and respiratory mechanics during compensatory lung growth. To investigate the structural and mechanical changes during compensatory growth, mice were studied for 21 days after left pneumonectomy using microCT and respiratory system impedance (FlexiVent). Anatomic changes after left pneumonectomy included minimal mediastinal shift or chestwall remodeling, but significant displacement of the heart and cardiac lobe. Mean displacement of the cardiac lobe centroid was 5.2 ± 0.8 mm. Lung impedance measurements were used to investigate the associated changes in respiratory mechanics. Quasi-static pressure-volume loops demonstrated progressive increase in volumes with decreased distensibility. Measures of quasi-static compliance and elastance were increased at all time points postpneumonectomy (P < .01). Oscillatory mechanics demonstrated a significant change in tissue impedance on the third day after pneumonectomy. The input impedance on day 3 after pneumonectomy demonstrated a significant increase in tissue damping (5.8 versus 4.3 cm H(2)O/mL) and elastance (36.7 versus 26.6 cm H(2)O/mL) when compared to controls. At all points, hysteresivity was unchanged (0.17). We conclude that the timing and duration of the mechanical changes was consistent with a mechanical signal for compensatory growth.
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Registered trials
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