Evidence map›Paper›PMID 22905670›Full record

SynthesisObesity reviews : an official journal of the International Association for the Study of Obesity2012

Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors.

F L Santos, S S Esteves, A da Costa Pereira, W S Yancy, J P L Nunes

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02519309 (Dietary Intervention in Type-2 Diabetics and Pre-Diabetics Emphasizing Personalized Carbohydrate Intake), which is not on this map. Cited by 126 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 13 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02519309 nacompletednot on this mapstarted 2015, after this paper: background citation

Dietary Intervention in Type-2 Diabetics and Pre-Diabetics Emphasizing Personalized Carbohydrate Intake

TypeinterventionalSponsorVirta HealthRan2015 to 2021Enrolled465ConditionsDiabetes Mellitus, Type 2, Pre-diabetes, Metabolic SyndromeArmsVirta Program
3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 13 syntheses or guidelines pooled it, 313 citations in OpenAlex.

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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

F L SantosCentro Hospitalar Vila Nova Gaia/Espinho, Gaia, Portugal Centro Hospitalar do Porto, Porto, Portugal.
S S Esteves
A da Costa Pereira
W S Yancy
J P L Nunes
Universidade do Porto · PTCentro Hospitalar de Vila Nova de Gaia · PTCentro Hospitalar do Porto · PTDuke Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A systematic review and meta-analysis were carried out to study the effects of low-carbohydrate diet (LCD) on weight loss and cardiovascular risk factors (search performed on PubMed, Cochrane Central Register of Controlled Trials and Scopus databases). A total of 23 reports, corresponding to 17 clinical investigations, were identified as meeting the pre-specified criteria. Meta-analysis carried out on data obtained in 1,141 obese patients, showed the LCD to be associated with significant decreases in body weight (-7.04 kg [95% CI -7.20/-6.88]), body mass index (-2.09 kg m(-2) [95% CI -2.15/-2.04]), abdominal circumference (-5.74 cm [95% CI -6.07/-5.41]), systolic blood pressure (-4.81 mm Hg [95% CI -5.33/-4.29]), diastolic blood pressure (-3.10 mm Hg [95% CI -3.45/-2.74]), plasma triglycerides (-29.71 mg dL(-1) [95% CI -31.99/-27.44]), fasting plasma glucose (-1.05 mg dL(-1) [95% CI -1.67/-0.44]), glycated haemoglobin (-0.21% [95% CI -0.24/-0.18]), plasma insulin (-2.24 micro IU mL(-1) [95% CI -2.65/-1.82]) and plasma C-reactive protein, as well as an increase in high-density lipoprotein cholesterol (1.73 mg dL(-1) [95%CI 1.44/2.01]). Low-density lipoprotein cholesterol and creatinine did not change significantly, whereas limited data exist concerning plasma uric acid. LCD was shown to have favourable effects on body weight and major cardiovascular risk factors; however the effects on long-term health are unknown.

Indexed as

Diet, Carbohydrate-RestrictedRandomized Controlled Trials as TopicBlood GlucoseBlood PressureCardiovascular DiseasesCholesterolDietary CarbohydratesHumansInsulinRisk FactorsTreatment OutcomeTriglyceridesWeight LossBlood GlucoseCholesterolDietary CarbohydratesInsulinTriglycerides

Identifiers

PMID22905670
OpenAlexW2110483590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.