ArticlePsychological methods2012
Assessing mediation using marginal structural models in the presence of confounding and moderation.
Article in Psychological methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- HEART Camp Connect-Promoting adherence to exercise in adults with heart failure with preserved ejection fraction.ESC heart failure · 2025Trial
- Improved Child Feces Management Mediates Reductions in Childhood Diarrhea from an On-Site Sanitation Intervention: Causal Mediation Analysis of a Cluster-Randomized Trial in Rural Bangladesh.Journal of epidemiology and global health · 2024Trial
- The double-burden of poverty on cognition hypothesis: a systematic review of the mechanisms of the effect of poverty in early life on the development and expression of cognition in adolescence and adulthood.Social psychiatry and psychiatric epidemiology · 2026Review
- The mediating role of recreational physical activity and dietary behavior in the relationship between family affluence and mental well-being: an interventional effects approach.Journal of behavioral medicine · 2026Article
- Role of social-cognitive factors in the relationship between e-cigarette use and subsequent cigarette smoking among U.S. youth: A causal mediation analysis.Addictive behaviors · 2025Article
- Practical challenges in mediation analysis: a guide for applied researchers.Health services & outcomes research methodology · 2025Article
- Tutorial on causal mediation analysis with binary variables: An application to health psychology research.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Facilitation of team-based care to improve HTN management and outcomes: a protocol for a randomized stepped wedge trial.BMC health services research · 2023Article
- Testing for mediation effect with application to human microbiome data.Statistics in biosciences · 2021Article
- Association of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study.JAMA network open · 2021Observational
- Article
- A biologist's guide to model selection and causal inference.Proceedings. Biological sciences · 2021Article
- Poor Health and Violent Crime Hot Spots: Mitigating the Undesirable Co-Occurrence Through Focused Place-Based Interventions.American journal of preventive medicine · 2020Article
- Patient information, communication and competence empowerment in oncology (PIKKO) - evaluation of a supportive care intervention for overall oncological patients. Study protocol of a non-randomized controlled trial.BMC medical research methodology · 2020Article
- Estimating long-term pollution exposure effects through inverse probability weighting methods with Cox proportional hazards models.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Causal Mediation Analysis in the Presence of Post-treatment Confounding Variables: A Monte Carlo Simulation Study.Frontiers in psychology · 2020Article
- Mediation analysis for estimating cardioprotection of longitudinal RAS inhibition beyond lowering blood pressure and albuminuria in type 1 diabetes.Annals of epidemiology · 2020Article
- Examining Intervention Component Dosage Effects on Substance Use Initiation in the Strengthening Families Program: for Parents and Youth Ages 10-14.Prevention science : the official journal of the Society for Prevention Research · 2019Article
- Inverse Propensity Score Weighting with a Latent Class Exposure: Estimating the Causal Effect of Reported Reasons for Alcohol Use on Problem Alcohol Use 16 Years Later.Prevention science : the official journal of the Society for Prevention Research · 2019Article
- Genetically Informative Mediation Modeling Applied to Stressors and Personality-Disorder Traits in Etiology of Alcohol Use Disorder.Behavior genetics · 2019Article
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2 authors.
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Abstract
This article presents marginal structural models with inverse propensity weighting (IPW) for assessing mediation. Generally, individuals are not randomly assigned to levels of the mediator. Therefore, confounders of the mediator and outcome may exist that limit causal inferences, a goal of mediation analysis. Either regression adjustment or IPW can be used to take confounding into account, but IPW has several advantages. Regression adjustment of even one confounder of the mediator and outcome that has been influenced by treatment results in biased estimates of the direct effect (i.e., the effect of treatment on the outcome that does not go through the mediator). One advantage of IPW is that it can properly adjust for this type of confounding, assuming there are no unmeasured confounders. Further, we illustrate that IPW estimation provides unbiased estimates of all effects when there is a baseline moderator variable that interacts with the treatment, when there is a baseline moderator variable that interacts with the mediator, and when the treatment interacts with the mediator. IPW estimation also provides unbiased estimates of all effects in the presence of nonrandomized treatments. In addition, for testing mediation we propose a test of the null hypothesis of no mediation. Finally, we illustrate this approach with an empirical data set in which the mediator is continuous, as is often the case in psychological research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.