SynthesisPloS one2012
A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Suicidal risk in patients with aggression in schizophrenia: a systematic review.Frontiers in psychiatry · 2025Pooled it
- The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.Neuromolecular medicine · 2016Pooled it
- Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility.Biomolecules · 2025Article
- Peak alpha frequency and electroencephalographic microstates are correlated with aggression in schizophrenia.Journal of psychiatric research · 2024Article
- An Exploration of Depression and Aggression Among Patients with Schizophrenia in China Rural Community.Psychology research and behavior management · 2024Article
- The association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia.Brain and behavior · 2022Article
- Forensic Value of Genetic Variants Associated with Anti-Social Behavior.Diagnostics (Basel, Switzerland) · 2021Review
- Childhood Trauma, the Combination of MAO-A and COMT Genetic Polymorphisms and the Joy of Being Aggressive in Forensic Psychiatric Patients.Brain sciences · 2021Article
- Aggressive Behavior and Psychiatric Inpatients: a Narrative Review of the Literature with a Focus on the European Experience.Current psychiatry reports · 2021Review
- Aggressive behavior in psychiatric patients in relation to hormonal imbalance (Review).Experimental and therapeutic medicine · 2020Review
- Haplotypic and Genotypic Association of Catechol-Frontiers in pharmacology · 2018Article
- New Clinically Relevant Findings about Violence by People with Schizophrenia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Review
- Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI andNeuropsychiatric disease and treatment · 2017Article
- Exploring the Dependence of QM/MM Calculations of Enzyme Catalysis on the Size of the QM Region.The journal of physical chemistry. B · 2016Article
- Genetic and environmental determinants of violence risk in psychotic disorders: a multivariate quantitative genetic study of 1.8 million Swedish twins and siblings.Molecular psychiatry · 2016Article
- Role of CB2 receptors in social and aggressive behavior in male mice.Psychopharmacology · 2015Article
- Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies.Current neuropharmacology · 2015Review
- Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission.Frontiers in behavioral neuroscience · 2014Review
- Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort.Journal of psychiatric research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a meta-analysis of studies examining the association between the Val158Met COMT polymorphism and violence against others in schizophrenia. A systematic search current to November 1, 2011 was conducted using MEDLINE, EMBASE, CINAHL, PsycINFO, ProQuest, and the National Criminal Justice Reference Service and identified 15 studies comprising 2,370 individuals with schizophrenia for inclusion. Bivariate analyses of study sensitivities and specificities were conducted. This methodology allowed for the calculation of pooled diagnostic odds ratios (DOR). Evidence of a significant association between the presence of a Met allele and violence was found such that men's violence risk increased by approximately 50% for those with at least one Met allele compared with homozygous Val individuals (DOR = 1.45; 95% CI = 1.05-2.00; z = 2.37, p = 0.02). No significant association between the presence of a Met allele and violence was found for women or when outcome was restricted to homicide. We conclude that male schizophrenia patients who carry the low activity Met allele in the COMT gene are at a modestly elevated risk of violence. This finding has potential implications for the pharmacogenetics of violent behavior in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.