Evidence map›Paper›PMID 22905215›Full record

Trial reportPloS one2012

A 14-item Mediterranean diet assessment tool and obesity indexes among high-risk subjects: the PREDIMED trial.

Miguel Angel Martínez-González, Ana García-Arellano, Estefanía Toledo, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Dolores Corella, Maria Isabel Covas, Helmut Schröder, Fernando Arós, Enrique Gómez-Gracia and 11 more

7 registry-linked trialsAbstract readClinical Trial
In one paragraph

Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 665 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
665citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04439877 completednot on this mapstarted 2018, after this paper: background citation

Exploring the Relationship Among Dental Caries, Nutritional Habits and Peri-implantitis

TypeobservationalSponsorUniversitat Internacional de CatalunyaRan2018 to 2020Enrolled169ConditionsPeri-Implantitis, Mucositis, Caries,Dental, NutritionArmsPeri-implant disease diagnosis
NCT05375513 narecruitingnot on this mapstarted 2023, after this paper: background citation

A Home-based Personalized Multidomain RCT from the Canadian Therapeutic Platform for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP)

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2023 to 2026Enrolled275ConditionsMild Cognitive ImpairmentArmsPMI@Home, Brain Health Pro
NCT06057324 naenrolling by invitationnot on this mapstarted 2023, after this paper: background citation

Switching Mediterranean Consumers to Mediterranean Sustainable Healthy Dietary Patterns by Combining Digital Interactive Tools with Targeted Educational Material and Sustainable Snacks

TypeinterventionalSponsorFundació EurecatRan2023 to 2025Enrolled480ConditionsHealthy Subjects, Behavior, Health, FamilyArmsAI-based Apps, Mediterranean-based diet toolkit and activities, Healthy plant-based snacks, AI-based Apps + Mediterranean-based diet toolkit and activities, AI-based Apps + Healthy plant-based snacks
NCT06415383 phase1completednot on this mapstarted 2024, after this paper: background citation

Testing the Effects of High-dose Vitamin B6 Supplements on Pain Thresholds and Tolerance in Healthy Adults

TypeinterventionalSponsorUniversity of ReadingRan2024 to 2025Enrolled43ConditionsPainArmsVitamin B6 100 MG, Placebo
NCT06681740 narecruitingnot on this mapstarted 2024, after this paper: background citation

CARDIOINSPIRE - Effectiveness of Adding Inspiratory Muscle Training to a Cardiac Rehabilitation Program for People With Ischemic Heart Disease Revascularized by Percutaneous Transluminal Coronary Angioplasty.

TypeinterventionalSponsorUniversity of CadizRan2024 to 2026Enrolled72ConditionsMyocardial Ischemia, Coronary Arterial Disease (CAD)ArmsInspiratory muscle training, Sham Inspiratory muscle training
NCT06873685 narecruitingnot on this mapstarted 2025, after this paper: background citation

Soft Tissue Sarcoma: Instrumented Evaluation of Motor Performance and Impact of Robotic Rehabilitation, Nutrition and Quality of Life Assessment (START-RUN1)

TypeinterventionalSponsorFondazione Policlinico Universitario Campus Bio-MedicoRan2025 to 2026Enrolled120ConditionsSarcoma, Soft TissueArmsRehabilitation
NCT07403929 narecruitingnot on this mapstarted 2026, after this paper: background citation

Determination of the Effect of Fermented Grape Juice Consumption on Oxidative Stress and Inflammation Biomarkers and SIRT-1 Levels in Fibromyalgia Patients

TypeinterventionalSponsorHacettepe UniversityRan2026 to 2027Enrolled45ConditionsFibromyalgia, Fibromyalgia (FM), Fibromyalgia Syndrome, PrimaryArmsMedical Nutrition Therapy (MNT), Hardaliye (200 mL/day)
3 · Its place in the literature

Who cites it

665 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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605 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Miguel Angel Martínez-GonzálezPrevención con Dieta Mediterránea Network RD 06/0045, Instituto de Salud Carlos III, Spanish Government, Madrid, Spain. mamartinez@unav.es
Ana García-Arellano
Estefanía Toledo
Jordi Salas-Salvadó
Pilar Buil-Cosiales
Dolores Corella
Maria Isabel Covas
Helmut Schröder
Fernando Arós
Enrique Gómez-Gracia
Miquel Fiol
Valentina Ruiz-Gutiérrez
José Lapetra
Rosa Maria Lamuela-Raventos
Lluís Serra-Majem
Xavier Pintó
Miguel Angel Muñoz
Julia Wärnberg
Emilio Ros
Ramón Estruch
PREDIMED Study Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIndependently of total caloric intake, a better quality of the diet (for example, conformity to the Mediterranean diet) is associated with lower obesity risk. It is unclear whether a brief dietary assessment tool, instead of full-length comprehensive methods, can also capture this association. In addition to reduced costs, a brief tool has the interesting advantage of allowing immediate feedback to participants in interventional studies. Another relevant question is which individual items of such a brief tool are responsible for this association. We examined these associations using a 14-item tool of adherence to the Mediterranean diet as exposure and body mass index, waist circumference and waist-to-height ratio (WHtR) as outcomes.

designCross-sectional assessment of all participants in the "PREvención con DIeta MEDiterránea" (PREDIMED) trial. SUBJECTS: 7,447 participants (55-80 years, 57% women) free of cardiovascular disease, but with either type 2 diabetes or ≥ 3 cardiovascular risk factors. Trained dietitians used both a validated 14-item questionnaire and a full-length validated 137-item food frequency questionnaire to assess dietary habits. Trained nurses measured weight, height and waist circumference.

resultsStrong inverse linear associations between the 14-item tool and all adiposity indexes were found. For a two-point increment in the 14-item score, the multivariable-adjusted differences in WHtR were -0.0066 (95% confidence interval, -0.0088 to -0.0049) for women and -0.0059 (-0.0079 to -0.0038) for men. The multivariable-adjusted odds ratio for a WHtR>0.6 in participants scoring ≥ 10 points versus ≤ 7 points was 0.68 (0.57 to 0.80) for women and 0.66 (0.54 to 0.80) for men. High consumption of nuts and low consumption of sweetened/carbonated beverages presented the strongest inverse associations with abdominal obesity.

conclusionsA brief 14-item tool was able to capture a strong monotonic inverse association between adherence to a good quality dietary pattern (Mediterranean diet) and obesity indexes in a population of adults at high cardiovascular risk.

Indexed as

Diet, MediterraneanFeeding BehaviorSurveys and QuestionnairesAgedAged, 80 and overBody Mass IndexCross-Sectional StudiesDietFemaleHumansMaleMiddle AgedObesityOdds RatioRiskWaist Circumference

Identifiers

PMID22905215
PMCPMC3419206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.