ArticlePloS one2012
Analysis of the gut microbiota in the old order Amish and its relation to the metabolic syndrome.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 6 of them syntheses that pooled it.
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Who cites it
119 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- MNEMONIC: MetageNomic Experiment Mining to create an OTU Network of Inhabitant Correlations.BMC bioinformatics · 2019Pooled it
- Meta-analysis of gut microbiome studies identifies disease-specific and shared responses.Nature communications · 2017Pooled it
- Pooled it
- Meta-analyses of human gut microbes associated with obesity and IBD.FEBS letters · 2014Pooled it
- Meta-analyses of studies of the human microbiota.Genome research · 2013Pooled it
- Gut microbiota phenotypes of obesity.NPJ biofilms and microbiomesPooled it
- Apple cider vinegar soaks do not alter the skin bacterial microbiome in atopic dermatitis.PloS one · 2021Trial
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- Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent Clostridium difficile infection.The ISME journal · 2014Trial
- Characterization of the Stool Microbiome in Hispanic Preschool Children by Weight Status and Time.Childhood obesity (Print)Trial
- A Review of Gut Microbiota Dynamics: From Healthy Gestation to Gestational Diabetes in Human and Mouse Models.Biomedicines · 2026Review
- Article
- Identification of microbiome markers for ordered groups.Genes & genomics · 2025Article
- Vitamin biosynthesis in the gut: interplay between mammalian host and its resident microbiota.Microbiology and molecular biology reviews : MMBR · 2025Review
- Scalable log-ratio lasso regression for enhanced microbial feature selection with FLORAL.Cell reports methods · 2024Article
- mbDecoda: a debiased approach to compositional data analysis for microbiome surveys.Briefings in bioinformatics · 2024Article
- Microbiota, natural products, and human health: exploring interactions for therapeutic insights.Frontiers in cellular and infection microbiology · 2024Review
- Enhanced Feature Selection for Microbiome Data using FLORAL: Scalable Log-ratio Lasso Regression.bioRxiv : the preprint server for biology · 2023Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Obesity has been linked to the human gut microbiota; however, the contribution of gut bacterial species to the obese phenotype remains controversial because of conflicting results from studies in different populations. To explore the possible dysbiosis of gut microbiota in obesity and its metabolic complications, we studied men and women over a range of body mass indices from the Old Order Amish sect, a culturally homogeneous Caucasian population of Central European ancestry. We characterized the gut microbiota in 310 subjects by deep pyrosequencing of bar-coded PCR amplicons from the V1-V3 region of the 16S rRNA gene. Three communities of interacting bacteria were identified in the gut microbiota, analogous to previously identified gut enterotypes. Neither BMI nor any metabolic syndrome trait was associated with a particular gut community. Network analysis identified twenty-two bacterial species and four OTUs that were either positively or inversely correlated with metabolic syndrome traits, suggesting that certain members of the gut microbiota may play a role in these metabolic derangements.
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Registered trials
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