ArticlePloS one2012
Arabidopsis MDA1, a nuclear-encoded protein, functions in chloroplast development and abiotic stress responses.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Meta-QTL analysis and in-silico transcriptome assessment for controlling chlorophyll traits in common wheat.The plant genome · 2023Pooled it
- Review
- The Impact of Mitochondrial DNA Depletion on Mitochondrial Ultrastructure, Photosynthesis, and the mTERF Gene Family inInternational journal of molecular sciences · 2026Article
- Smi-miRmTERF regulates organelle development, retrograde signaling, secondary metabolism and immunity via targeting a subset of SmmTERFs in Salvia miltiorrhiza.Molecular horticulture · 2025Article
- Physiology, genomics, and evolutionary aspects of desert plants.Journal of advanced research · 2024Review
- Transcriptome Shock in Developing Embryos of aInternational journal of molecular sciences · 2023Article
- Analysis of the TomatoPlants (Basel, Switzerland) · 2023Article
- Article
- Natural variation identifies new effectors of water-use efficiency inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Plant ecological genomics at the limits of life in the Atacama Desert.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Combined analysis of carotenoid metabolites and the transcriptome to reveal the molecular mechanism underlying fruit colouration in zucchini (Food chemistry. Molecular sciences · 2021Article
- Meta-Analysis of Quantitative Traits Loci (QTL) Identified in Drought Response in Rice (Plants (Basel, Switzerland) · 2021Article
- Article
- Mitochondrial Transcription Termination Factor 27 Is Required for Salt Tolerance inInternational journal of molecular sciences · 2021Article
- Review
- Identification of QTLs Controlling Salt Tolerance in Cucumber (Plants (Basel, Switzerland) · 2021Article
- Identification, Characterization, and Expression Profile Analysis of theFrontiers in plant science · 2021Article
- The Arabidopsis mTERF-repeat MDA1 protein plays a dual function in transcription and stabilization of specific chloroplast transcripts within the psbE and ndhH operons.The New phytologist · 2020Article
- The Role of Chloroplast Gene Expression in Plant Responses to Environmental Stress.International journal of molecular sciences · 2020Review
- Arabidopsis Plastid-RNA Polymerase RPOTp Is Involved in Abiotic Stress Tolerance.Plants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most chloroplast and mitochondrial proteins are encoded by nuclear genes, whose functions remain largely unknown because mutant alleles are lacking. A reverse genetics screen for mutations affecting the mitochondrial transcription termination factor (mTERF) family in Arabidopsis thaliana allowed us to identify 75 lines carrying T-DNA insertions. Two of them were homozygous for insertions in the At4g14605 gene, which we dubbed MDA1 (MTERF DEFECTIVE IN Arabidopsis1). The mda1 mutants exhibited altered chloroplast morphology and plant growth, and reduced pigmentation of cotyledons, leaves, stems and sepals. The mda1 mutations enhanced salt and osmotic stress tolerance and altered sugar responses during seedling establishment, possibly as a result of reduced ABA sensitivity. Loss of MDA1 function caused up-regulation of the RpoTp/SCA3 nuclear gene encoding a plastid RNA polymerase and modified the steady-state levels of chloroplast gene transcripts. Double mutant analyses indicated that MDA1 and the previously described mTERF genes SOLDAT10 and RUG2 act in different pathways. Our findings reveal a new role for mTERF proteins in the response to abiotic stress, probably through perturbed ABA retrograde signalling resulting from a disruption in chloroplast homeostasis.
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