ArticlePloS one2012
MLVA16 typing of Portuguese human and animal Brucella melitensis and Brucella abortus isolates.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 58 citations in OpenAlex.
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- First record of the human infection of Brucella melitensis in Kyrgyzstan: evidence from whole-genome sequencing-based analysis.Infectious diseases of poverty · 2022Article
- Identification and molecular characterization of Brucella abortus and Brucella melitensis isolated from milk in cattle in Azerbaijan.BMC veterinary research · 2022Article
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- Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China.Emerging microbes & infections · 2020Article
- Genetic variation of Brucella isolates at strain level in Egypt.Veterinary medicine and science · 2020Article
- MLVA-16 Genotyping ofPathogens (Basel, Switzerland) · 2020Article
- Genome-scale approach to study the genetic relatedness among Brucella melitensis strains.PloS one · 2020Article
- Investigation of the molecular characteristics of Brucella isolates from Guangxi Province, China.BMC microbiology · 2019Article
- Phenotypic and genotypic characteristics of Brucella isolates from the Republic of Kazakhstan.Tropical animal health and production · 2019Article
- Molecular characterization of Brucella species from Zimbabwe.PLoS neglected tropical diseases · 2019Article
- Genetic Diversity ofFrontiers in microbiology · 2019Article
- Molecular Investigation of the Transmission Pattern ofFrontiers in veterinary science · 2018Article
- Origins and global context of Brucella abortus in Italy.BMC microbiology · 2017Article
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Authors and funding
12 authors at 7 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
To investigate the epidemiological relationship of isolates from different Portuguese geographical regions and to assess the diversity among isolates, the MLVA16(Orsay) assay (panels 1, 2A and 2B) was performed with a collection of 126 Brucella melitensis (46 human and 80 animal isolates) and 157 B. abortus field isolates, seven vaccine strains and the representative reference strains of each species. The MLVA16(Orsay) showed a similar high discriminatory power (HGDI 0.972 and 0.902) for both species but panel 1 and 2A markers displayed higher diversity (HGDI 0.693) in B. abortus compared to B. melitensis isolates (HGDI 0.342). The B. melitensis population belong to the "Americas" (17%) and "East Mediterranean" (83%) groups. No isolate belonged to the "West Mediterranean" group. Eighty-five percent of the human isolates (39 in 46) fit in the "East-Mediterranean" group where a single lineage known as MLVA11 genotype 116 is responsible for the vast majority of Brucella infections in humans. B. abortus isolates formed a consistent group with bv1 and bv3 isolates in different clusters. Four MLVA11 genotypes were observed for the first time in isolates from S. Jorge and Terceira islands from Azores. From the collection of isolates analysed in this study we conclude that MLVA16(Orsay) provided a clear view of Brucella spp. population, confirming epidemiological linkage in outbreak investigations. In particular, it suggests recent and ongoing colonisation of Portugal with one B. melitensis lineage usually associated with East Mediterranean countries.
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