ArticlePloS one2012
Cholecystolithiasis is associated with Clonorchis sinensis infection.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Trial
- Disability-adjusted life years of clonorchiasis in China: a high-resolution spatial analysis.Infectious diseases of poverty · 2025Article
- Parasitic Gallbladder Infection: Case Study of Biliary Clonorchiasis in a Non-Endemic Region.The American journal of case reports · 2025Article
- Research of the clinical features, risk factors, and surgical diagnosis of intramural stones in patients with gallbladder stones.Scientific reports · 2025Article
- Formation of non-cholesterol gallstones in populations within clonorchiasis endemic regions is closely related to Clonorchis sinensis infection.BMC gastroenterology · 2025Article
- Assessment of the application of the FA280-a fully automated fecal analyzer for diagnosing clonorchiasis: a mixed-method study.Infectious diseases of poverty · 2025Article
- Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control.Clinical microbiology reviews · 2024Review
- Features of Metabolite Changes in Disease Evolution in Cholecystolithiasis.Digestive diseases and sciences · 2024Article
- Children education for sustainable control of liver fluke infections.Infectious diseases of poverty · 2022Article
- Association between the Dietary Inflammatory Index with gallstone disease: finding from Dena PERSIAN cohort.BMJ open gastroenterology · 2022Article
- Unexpected discovery ofClinical case reports · 2022Article
- Cost yield of different treatment strategies against Clonorchis sinensis infection.Infectious diseases of poverty · 2021Article
- Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea.BMC public health · 2021Article
- The Overactivation of NADPH Oxidase duringAntioxidants (Basel, Switzerland) · 2021Article
- An investigation ofFood and waterborne parasitology · 2021Article
- Severe hepatobiliary morbidity is associated with Clonorchis sinensis infection: The evidence from a cross-sectional community study.PLoS neglected tropical diseases · 2021Article
- Familial assimilation in transmission of raw-freshwater fish-eating practice leading to clonorchiasis.PLoS neglected tropical diseases · 2020Article
- Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors.BioMed research international · 2020Article
- Improving diagnostic performance of the Kato-Katz method for Clonorchis sinensis infection through multiple samples.Parasites & vectors · 2019Article
- Association of circulating inflammation proteins and gallstone disease.Journal of gastroenterology and hepatology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to analyze gallbladder stones for direct evidence of a relationship between Clonorchis sinensis infection and gallbladder stones formation. METHODOLOGY: We investigated one hundred eighty-three gallbladder stones for the presence of Clonorchis sinensis eggs using microscopy, and analyzed their composition using Fourier transform infrared spectroscopy. We confirmed the presence of Clonorchis sinensis eggs in the gallbladder stones using real-time fluorescent PCR and scanning electron microscopy. PRINCIPAL
findingsClonorchis sinensis eggs were detected in 122 of 183 gallbladder stones based on morphologic characteristics and results from real-time fluorescent PCR. The proportion of pigment stones, cholesterol stones and mixed gallstones in the egg-positive stones was 79.5% (97/122), 3.3% (4/122) and 17.2% (21/122), respectively, while 29.5% (18/61), 31.1% (19/61) and 39.3% (24/61) in the egg-negative stones. The proportion of pigment stone in the Clonorchis sinensis egg-positive stones was higher than in egg-negative stones (P<0.0001). In the 30 egg-positive stones examined by scanning electron microscopy, dozens or even hundreds of Clonorchis sinensis eggs were visible (×400) showing a distinct morphology. Many eggs were wrapped with surrounding particles, and in some, muskmelon wrinkles was seen on the surface of the eggs. Also visible were pieces of texture shed from some of the eggs. Some eggs were depressed or without operculum while most eggs were adhered to or wrapped with amorphous particles or mucoid matter (×3000).
conclusionClonorchis sinensis eggs were detected in the gallbladder stones which suggests an association between Clonorchis sinensis infection and gallbladder stones formation, especially pigment stones.
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