SynthesisPloS one2012
Is there an increased risk of post-operative surgical site infection after orthopaedic surgery in HIV patients? A systematic review and meta-analysis.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- [Prevention of postoperative infections : Risk factors and the current WHO guidelines in musculoskeletal surgery].Der Unfallchirurg · 2017Pooled it
- Long-term outcomes after knee endoprosthesis for a rare HIV-associated proximal tibial osteosarcoma: 15-year follow-up.Radiology case reports · 2026Article
- The value of preoperative CD4BMC infectious diseases · 2026Article
- Application of omental flap in total vaginectomy for post-radiotherapy recurrent cervical cancer: a case report.Frontiers in surgery · 2026Article
- Systemic immune-inflammation index as a novel biomarker for predicting surgical site infection in people living with HIV: a multicenter, retrospective cohort study.Frontiers in cellular and infection microbiology · 2026Observational
- Effect of clinical pharmacist's intervention on perioperative prophylaxis of antimicrobial drugs in AIDS patients.European journal of medical research · 2025Article
- Trends Following Lumbar Spine Fusion in People Living With Human Immunodeficiency Virus in New York State.Cureus · 2025Article
- Risk factors for surgical site infection after general surgery in HIV-infected patients: a retrospective study.BMC infectious diseases · 2024Article
- A New Start with HAART: Evaluating Breast Reconstruction in the Era of Highly Active Antiretroviral Therapy.Plastic and reconstructive surgery. Global open · 2024Article
- A novel web-based risk calculator for predicting surgical site infection in HIV-positive facture patients: a multicenter cohort study in China.Frontiers in cellular and infection microbiology · 2024Article
- The association between the CD4/CD8 ratio and surgical site infection risk among HIV-positive adults: insights from a China hospital.Frontiers in immunology · 2023Article
- The consensus guideline of perioperative antiviral therapy for AIDS patients in China based on clinical practice.Frontiers in medicine · 2023Article
- Total Hip Arthroplasty in Patients With Classic Hemophilia: A Matched Comparison of 90-Day Outcomes and 5-Year Implant Survival.The Journal of arthroplasty · 2022Article
- Impact of human immunodeficiency virus on 2-year revision rates following lumbar fusion for degenerative spinal conditions: a retrospective cohort study.Journal of spine surgery (Hong Kong) · 2021Article
- Experience with modified radical mastectomy in a low-income country: a multi-center prospective observational study.BMC surgery · 2021Observational
- [Surgical site infections-Prevention and treatment strategies].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Article
- Nomogram prediction of surgical site infection of HIV-infected patients following orthopedic surgery: a retrospective study.BMC infectious diseases · 2020Article
- Penile Prosthesis Infection: Myths and Realities.The world journal of men's health · 2019Review
- Minimizing Penile Implant Infection: A Literature Review of Patient and Surgical Factors.Current urology reports · 2015Review
- Complications after intramedullary nailing of femoral fractures in a low-income country.Acta orthopaedica · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is dilemma as to whether patients infected with the Human Immunodeficiency Virus (HIV) requiring implant orthopaedic surgery are at an increased risk for post-operative surgical site infection (SSI). We conducted a systematic review to determine the effect of HIV on the risk of post-operative SSI and sought to determine if this risk is altered by antibiotic use beyond 24 hours.
methodsWe searched electronic databases, manually searched citations from relevant articles, and reviewed conference proceedings. The risk of postoperative SSI was pooled using Mantel-Haenszel method.
resultsWe identified 18 cohort studies with 16 mainly small studies, addressing the subject. The pooled risk ratio of infection in the HIV patients when compared to non-HIV patients was 1.8 (95% Confidence Interval [CI] 1.3-2.4), in studies in Africa this was 2.3 (95% CI 1.5-3.5). In a sensitivity analysis the risk ratio was reduced to 1.4 (95% CI 0.5-3.8). The risk ratio of infection in patients receiving prolonged antibiotics compared to patients receiving antibiotics for up to 24 hours was 0.7 (95% CI 0.1-4.2).
conclusionsThe results may indicate an increased risk in HIV infected patients but these results are not robust and inconclusive after conducting the sensitivity analysis removing poor quality studies. There is need for larger good quality studies to provide conclusive evidence. To better develop surgical protocols, further studies should determine the effect of reduced CD4 counts, viral load suppression and prolonged antibiotics on the risk for infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.