Evidence map›Paper›PMID 22904374›Full record

ReviewLearning & memory (Cold Spring Harbor, N.Y.)2012

The molecular basis of cognitive deficits in pervasive developmental disorders.

Aditi Bhattacharya, Eric Klann

Open access · diamondAbstract readReview
In one paragraph

Review in Learning & memory (Cold Spring Harbor, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aditi BhattacharyaCenter for Neural Science, New York University, New York, New York 10003, USA.
Eric Klann
New York University · US

Funding

Translation Regulation in Hippocampal LTP and LTDR01NS047384 · NINDS · NEW YORK UNIVERSITY · PI KLANN, ERIC · 2005 to 2020
$5.2M
Reactive Oxygen Species Signaling in the HippocampusR01NS034007 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLANN, ERIC · 2000 to 2012
$4.2M
eIF2alpha Phosphorylation in Synaptic Plasticity, Memory, and Brain DisordersR37NS034007 · NINDS · NEW YORK UNIVERSITY · PI KLANN, ERIC · 2014 to 2020
$3.3M
OXIDATIVE ACTIVATION OF PKC DURING INDUCTION OF LTPR29NS034007 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLANN, ERIC · 1995 to 1999
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NINDS NIH HHS NS034007NINDS NIH HHS NS047384NINDS NIH HHS R01 NS034007NINDS NIH HHS R01 NS047384NINDS NIH HHS R29 NS034007NINDS NIH HHS R37 NS034007
6 · The paper itself

Abstract

Persons with pervasive developmental disorders (PDD) exhibit a range of cognitive deficits that hamper their quality of life, including difficulties involving communication, sociability, and perspective-taking. In recent years, a variety of studies in mice that model genetic syndromes with a high risk of PDD have provided insights into the underlying molecular mechanisms associated with these disorders. What is less appreciated is how the molecular anomalies affect neuronal and circuit function to give rise to the cognitive deficits associated with PDD. In this review, we describe genetic mutations that cause PDD and discuss how they alter fundamental social and cognitive processes. We then describe efforts to correct cognitive impairments associated with these disorders and identify areas of further inquiry in the search for molecular targets for therapeutics for PDD.

Indexed as

AnimalsBrainCell CommunicationChildChild Development Disorders, PervasiveChild, PreschoolCognition DisordersDNAEnergy MetabolismHumansQuality of LifeRNADNARNA

Identifiers

PMID22904374
PMCPMC3418762
OpenAlexW2324785277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.