ArticleJournal of the American Society of Nephrology : JASN2012
Tuberin inhibits production of the matrix protein fibronectin in diabetes.
Article in Journal of the American Society of Nephrology : JASN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 22 citations in OpenAlex.
- Galectin-1 is a new fibrosis protein in type 1 and type 2 diabetes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Kidney atrophy vs hypertrophy in diabetes: which cells are involved?Cell cycle (Georgetown, Tex.) · 2018Article
- Evaluation of mTOR signaling pathway proteins in rat gastric mucosa exposed to sulfite and ghrelin.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion.American journal of physiology. Cell physiology · 2017Article
- Novel protective mechanism of reducing renal cell damage in diabetes: Activation AMPK by AICAR increased NRF2/OGG1 proteins and reduced oxidative DNA damage.Cell cycle (Georgetown, Tex.) · 2016Article
- Calcitriol regulates angiotensin-converting enzyme and angiotensin converting-enzyme 2 in diabetic kidney disease.Molecular biology reports · 2016Article
- Activation of AMP-activated protein kinase prevents TGF-β1-induced epithelial-mesenchymal transition and myofibroblast activation.The American journal of pathology · 2015Article
- Novel mechanism of transcriptional regulation of cell matrix protein through CREB.Cell cycle (Georgetown, Tex.) · 2015Article
- Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes.Oncotarget · 2014Article
- The role of microRNAs in diabetic nephropathy.Journal of diabetes research · 2014Review
- Tuberin in renal cell hypertrophy.Cell cycle (Georgetown, Tex.) · 2014Article
- Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.Journal of the American Society of Nephrology : JASN · 2013Article
- Novel mechanism of regulation of fibrosis in kidney tumor with tuberous sclerosis.Molecular cancer · 2013Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Exposure of proximal tubular epithelial cells to high glucose contributes to the accumulation of tubulointerstitial and matrix proteins in diabetic nephropathy, but how this occurs is not well understood. We investigated the effect of the signaling molecule tuberin, which modulates the mammalian target of rapamycin pathway, on renal hypertrophy and fibronectin expression. We found that the kidney mass was significantly greater in partially tuberin-deficient (TSC2(+/-) ) diabetic rats than wild-type diabetic rats. Furthermore, TSC2(+/-) rats exhibited significant increases in the basal levels of phospho-tuberin and fibronectin expression in the kidney cortex. Increased levels of phosphorylated tuberin associated with an increase in fibronectin expression in both wild-type and TSC2(+/-) diabetic rats. Treatment with insulin abrogated the diabetes-induced increase in fibronectin expression. In vitro, high glucose enhanced fibronectin expression in TSC2(+/-) primary proximal tubular epithelial cells; both inhibition of Akt and inhibition of the mammalian target of rapamycin could prevent this effect of glucose. In addition, forced expression of tuberin in tuberin-null cells abolished the expression of fibronectin protein. Taken together, these data suggest that tuberin plays a central role in the development of renal hypertrophy and in modulating the production of the matrix protein fibronectin in diabetes.
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