ArticlePlant physiology2012
The effector SPRYSEC-19 of Globodera rostochiensis suppresses CC-NB-LRR-mediated disease resistance in plants.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 104 citations in OpenAlex.
- Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Adaptation of the Cyst Nematode Globodera pallida to the Colinear Potato Resistant QTLs GpaVMolecular ecology · 2025Article
- Identification through a transcriptomic approach of candidate genes involved in the adaptation of the cyst nematode Globodera pallida to the potato resistance factor GpaVBMC genomics · 2025Article
- Evolution of parasitism genes in the plant parasitic nematodes.Scientific reports · 2024Article
- AFrontiers in plant science · 2024Article
- Unmasking the invaders: NLR-mal function in plant defense.Frontiers in plant science · 2023Review
- Role of the Sw5 Gene Cluster in the Fight against Plant Viruses.Journal of virology · 2022Review
- Profiling the Proteome of Cyst Nematode-Induced Syncytia on Tomato Roots.International journal of molecular sciences · 2021Article
- Plant Parasitic Nematodes: A Review on Their Behaviour, Host Interaction, Management Approaches and Their Occurrence in Two Sites in the Republic of Ireland.Plants (Basel, Switzerland) · 2021Review
- Comparative genomics of two inbred lines of the potato cyst nematode Globodera rostochiensis reveals disparate effector family-specific diversification patterns.BMC genomics · 2021Article
- Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network.PLoS biology · 2021Article
- Agroinfiltration for transient gene expression and characterisation of fungal pathogen effectors in cool-season grain legume hosts.Plant cell reports · 2021Article
- Potato cyst nematodes Globodera rostochiensis and G. pallida.Molecular plant pathology · 2021Article
- The influence of competing root symbionts on below-ground plant resource allocation.Ecology and evolution · 2021Review
- Oxylipins are implicated as communication signals in tomato-root-knot nematode (Meloidogyne javanica) interaction.Scientific reports · 2021Article
- Molecular and Cellular Mechanisms Involved in Host-Specific Resistance to Cyst Nematodes in Crops.Frontiers in plant science · 2021Review
- Chorismate mutase and isochorismatase, two potential effectors of the migratory nematode Hirschmanniella oryzae, increase host susceptibility by manipulating secondary metabolite content of rice.Molecular plant pathology · 2020Article
- Screening soybean cyst nematode effectors for their ability to suppress plant immunity.Molecular plant pathology · 2020Article
- Initial responses of the trap-crop, Solanum sisymbriifolium, to Globodera pallida invasions.The plant genome · 2020Article
- Aphid populations showing differential levels of virulence on Capsicum accessions.Insect science · 2020Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potato cyst nematode Globodera rostochiensis invades roots of host plants where it transforms cells near the vascular cylinder into a permanent feeding site. The host cell modifications are most likely induced by a complex mixture of proteins in the stylet secretions of the nematodes. Resistance to nematodes conferred by nucleotide-binding-leucine-rich repeat (NB-LRR) proteins usually results in a programmed cell death in and around the feeding site, and is most likely triggered by the recognition of effectors in stylet secretions. However, the actual role of these secretions in the activation and suppression of effector-triggered immunity is largely unknown. Here we demonstrate that the effector SPRYSEC-19 of G. rostochiensis physically associates in planta with the LRR domain of a member of the SW5 resistance gene cluster in tomato (Lycopersicon esculentum). Unexpectedly, this interaction did not trigger defense-related programmed cell death and resistance to G. rostochiensis. By contrast, agroinfiltration assays showed that the coexpression of SPRYSEC-19 in leaves of Nicotiana benthamiana suppresses programmed cell death mediated by several coiled-coil (CC)-NB-LRR immune receptors. Furthermore, SPRYSEC-19 abrogated resistance to Potato virus X mediated by the CC-NB-LRR resistance protein Rx1, and resistance to Verticillium dahliae mediated by an unidentified resistance in potato (Solanum tuberosum). The suppression of cell death and disease resistance did not require a physical association of SPRYSEC-19 and the LRR domains of the CC-NB-LRR resistance proteins. Altogether, our data demonstrated that potato cyst nematodes secrete effectors that enable the suppression of programmed cell death and disease resistance mediated by several CC-NB-LRR proteins in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.