ReviewAmerican journal of physiology. Heart and circulatory physiology2012
The history of matrix metalloproteinases: milestones, myths, and misperceptions.
Review in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 169 citations in OpenAlex.
- Matrix metalloproteinase imaging and survival prospects with aging in murine aortic aneurysm.EJNMMI research · 2026Article
- Therapeutic potential of inhibitors of gelatinases MMP-2 and MMP-9 for the treatment of breast cancer.The FEBS journal · 2026Review
- Circulating matrix metalloproteinase profile in early-stage primary biliary cholangitis.Scientific reports · 2026Article
- A Degradomic Landscape of Proteolytic Remodeling in Melanoma Lung Metastasis.Journal of proteome research · 2026Article
- Matrix Metalloproteinase 14 in Corneal Neovascularization.International journal of molecular sciences · 2026Review
- Early Post-STEMI Cardiac Rehabilitation in the CSC-Infarct Program: Real-World Safety and Effectiveness of Individualized Training Protocols.Journal of clinical medicine · 2026Article
- Matrix Metalloproteinases in Inflammatory Dermatoses.International journal of molecular sciences · 2025Review
- 3D Contractile and Remodeling Behaviors of Functionally Normal and Prolapsed Human Mitral Valve Interstitial Cells.bioRxiv : the preprint server for biology · 2025Article
- Apolipoprotein-A1 transports and regulates MMP2 in the blood.Nature communications · 2025Article
- Potential target within the tumor microenvironment - MT1-MMP.Frontiers in immunology · 2025Review
- Expression ofExperimental and therapeutic medicine · 2024Article
- Evaluating the Therapeutic Effect of Hispidin on Prostate Cancer Cells.International journal of molecular sciences · 2024Article
- Bioactive Dressing: A New Algorithm in Wound Healing.Journal of clinical medicine · 2024Review
- Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application.Bioactive materials · 2024Review
- Article
- Therapeutic effects of myrrh extract and myrrh-based silver nanoparticles onFrontiers in veterinary science · 2024Article
- Proteomic sequencing analysis in a rat model of atrial fibrosis caused by chronic intermittent hypoxia.Journal of thoracic disease · 2023Article
- Paracrine regulation of neural crest EMT by placodal MMP28.PLoS biology · 2023Article
- Article
- Mechanical strain modulates extracellular matrix degradation and byproducts in an isoform-specific manner.Biochimica et biophysica acta. General subjects · 2023Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Since the discovery of tadpole collagenase in 1962, the matrix metalloproteinase (MMP) family has emerged as a significant proteinase group with recognized effects on the cardiovascular system. Over the last 40 years, many milestones have been achieved, from the identification of the first MMP, to the generation of the first MMP cDNA clone and null mouse, to the clinical approval of the first MMP inhibitor. Over the years, a few myths and misunderstandings have interwoven into the truths. In this review, we will discuss the major milestones of MMP research, as well as review the misinterpretations and misperceptions that have evolved. Clarifying the confusions and dispelling the myths will both provide a better understanding of MMP properties and functions and focus the cardiovascular field on the outstanding research questions that need to be addressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.