ArticleExperimental physiology2013
Elevated local skin temperature impairs cutaneous vasoconstrictor responses to a simulated haemorrhagic challenge while heat stressed.
Article in Experimental physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Normothermic central hypovolemia tolerance reflects hyperthermic tolerance.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2014Trial
- Acute volume expansion attenuates hyperthermia-induced reductions in cerebral perfusion during simulated hemorrhage.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Effects of electrode placement on electrical stimulation for wound healing.Scientific reports · 2025Article
- Efficiency of cutaneous heat diffusion after local hyperthermia for the treatment of itch.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- Neural control of blood pressure is altered following isolated leg heating in aged humans.American journal of physiology. Heart and circulatory physiology · 2020Article
- Impact of environmental stressors on tolerance to hemorrhage in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Elevated skin and core temperatures both contribute to reductions in tolerance to a simulated haemorrhagic challenge.Experimental physiology · 2017Article
- Fluid restriction during exercise in the heat reduces tolerance to progressive central hypovolaemia.Experimental physiology · 2015Article
- Human cardiovascular responses to passive heat stress.Comprehensive Physiology · 2015Review
- Active and passive heat stress similarly compromise tolerance to a simulated hemorrhagic challenge.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Blunted cutaneous vasoconstriction and increased frequency of presyncope during an orthostatic challenge under moderate heat stress in the morning.European journal of applied physiology · 2014Article
- Blood pressure regulation X: what happens when the muscle pump is lost? Post-exercise hypotension and syncope.European journal of applied physiology · 2014Review
- Blood pressure regulation III: what happens when one system must serve two masters: temperature and pressure regulation?European journal of applied physiology · 2014Review
- The use of local concentrated heat versus topical acyclovir for a herpes labialis outbreak: results of a pilot study under real life conditions.Clinical, cosmetic and investigational dermatology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
During a simulated haemorrhagic challenge, syncopal symptoms develop sooner when individuals are hyperthermic relative to normothermic. This is due, in part, to a large displacement of blood to the cutaneous circulation during hyperthermia, coupled with inadequate cutaneous vasoconstriction during the hypotensive challenge. The influence of local skin temperature on these cutaneous vasoconstrictor responses is unclear. This project tested the hypothesis that local skin temperature modulates cutaneous vasoconstriction during simulated haemorrhage in hyperthermic humans. Eight healthy participants (four men and four women; 32 ± 7 years old; 75.2 ± 10.8 kg) underwent lower-body negative pressure to presyncope while heat stressed via a water-perfused suit sufficiently to increase core temperature by 1.2 ± 0.2 °C. At forearm skin sites distal to the water-perfused suit, local skin temperature was either 35.2 ± 0.6 (mild heating) or 38.2 ± 0.2 °C (moderate heating) throughout heat stress and lower-body negative pressure, and remained at these temperatures until presyncope. The reduction in cutaneous vascular conductance during the final 90 s of lower-body negative pressure, relative to heat-stress baseline, was greatest at the mildly heated site (-10 ± 15% reduction) relative to the moderately heated site (-2 ± 12%; P = 0.05 for the magnitude of the reduction in cutaneous vascular conductance between sites), because vasoconstriction at the moderately heated site was either absent or negligible. In hyperthermic individuals, the extent of cutaneous vasoconstriction during a simulated haemorrhage can be modulated by local skin temperature. In situations where skin temperature is at least 38 °C, as is the case in soldiers operating in warm climatic conditions, a haemorrhagic insult is unlikely to be accompanied by cutaneous vasoconstriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.