ArticleThe European respiratory journal2013
Differences between asthmatics and nonasthmatics hospitalised with influenza A infection.
Article in The European respiratory journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Corticosteroids as adjunctive therapy in the treatment of influenza.The Cochrane database of systematic reviews · 2019Pooled it
- Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data.The Lancet. Respiratory medicine · 2014Pooled it
- Exacerbations and Management of Asthma in Viral Lower Respiratory Tract Infections: The Significance of Immunoglobulin E.Immunity, inflammation and disease · 2026Review
- Clinical practice guidelines for the treatment and prophylaxis of influenza in China (2025 edition).Infectious diseases & immunity · 2026Article
- Adherence to application technique of inhaled corticosteroid in patients with asthma and COVID-19 improves outcomes.BMJ open respiratory research · 2024Article
- Eosinophils as potential biomarkers in respiratory viral infections.Frontiers in immunology · 2023Review
- Effect of neuraminidase inhibitor (oseltamivir) treatment on outcome of hospitalised influenza patients, surveillance data from 11 EU countries, 2010 to 2020.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Article
- Outcomes and risk factors with COVID-19 or influenza in hospitalized asthma patients.Respiratory research · 2022Article
- No evidence of harmful effects of steroids in severe exacerbations of COPD associated with influenza.Infection · 2022Article
- Asthma and COVID-19: an update.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Impact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study.Scientific reports · 2021Article
- Influenza A virus directly modulates mouse eosinophil responses.Journal of leukocyte biology · 2020Article
- Weathering the Cytokine Storm in Susceptible Patients with Severe SARS-CoV-2 Infection.The journal of allergy and clinical immunology. In practice · 2020Article
- Insights Into Type I and III Interferons in Asthma and Exacerbations.Frontiers in immunology · 2020Review
- Allergic inflammation alters the lung microbiome and hinders synergistic co-infection with H1N1 influenza virus and Streptococcus pneumoniae in C57BL/6 mice.Scientific reports · 2019Article
- Determinants of Fatal Outcome in Patients Admitted to Intensive Care Units With Influenza, European Union 2009-2017.Open forum infectious diseases · 2019Article
- Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza.The European respiratory journal · 2019Observational
- Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma: The Role of Metapneumovirus, Bocavirus and Influenza Virus.Immunology and allergy clinics of North America · 2019Review
- Epidemiology of Infections and Development of Asthma.Immunology and allergy clinics of North America · 2019Review
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Abstract
Asthmatics hospitalised because of influenza A infection are less likely to require intensive care or die compared with nonasthmatics. The reasons for this are unknown. We performed a retrospective analysis of data on 1520 patients admitted to 75 UK hospitals with confirmed influenza A/H1N1 2009 infection. A multivariable model was used to investigate reasons for the association between asthma and severe outcomes (intensive care unit support or death). Asthmatics were less likely than nonasthmatics to have severe outcome (11.2% versus 19.8%, unadjusted OR 0.51, 95% CI 0.36-0.72) despite a greater proportion requiring oxygen on admission (36.4% versus 26%, unadjusted OR 1.63) and similar rates of pneumonia (17.1% versus 16.6%, unadjusted OR 1.04). The results of multivariable logistic regression suggest the association of asthma with outcome (adjusted OR 0.62, 95% CI 0.36-1.05; p=0.075) are explained by pre-admission inhaled corticosteroid use (adjusted OR 0.34, 95% CI 0.18-0.66) and earlier admission (≤ 4 days from symptom onset) (adjusted OR 0.60, 95% CI 0.38-0.94). In asthmatics, systemic corticosteroids were associated with a decreased likelihood of severe outcomes (adjusted OR 0.36, 95% CI 0.18-0.72). Corticosteroid use and earlier hospital admission explained the association of asthma with less severe outcomes in hospitalised patients.
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