ArticleJournal of biophotonics2013
Synergy of photoacoustic and fluorescence flow cytometry of circulating cells with negative and positive contrasts.
Article in Journal of biophotonics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05301348 (In Vivo Detection of Circulating Clots in Patients With Thromboembolism), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
In Vivo Detection of Circulating Clots in Patients With Thromboembolism
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review.Journal of biomedical optics · 2024Pooled it
- Chip-Based Optoacoustic Single-Cell Detection in Flow Using Point-Source Optimized Surface Acoustic Wave Transducers.ACS applied materials & interfaces · 2025Article
- Deep learning-enabled detection of rare circulating tumor cell clusters in whole blood using label-free, flow cytometry.Lab on a chip · 2024Article
- Deep Learning-Enabled, Detection of Rare Circulating Tumor Cell Clusters in Whole Blood Using Label-free, Flow Cytometry.bioRxiv : the preprint server for biology · 2023Article
- Label-free flow cytometry of rare circulating tumor cell clusters in whole blood.Scientific reports · 2022Article
- Development of Metal-Organic Framework-Based Dual Antibody Nanoparticles for the Highly Specific Capture and Gradual Release of Circulating Tumor Cells.Frontiers in bioengineering and biotechnology · 2022Review
- Noninvasive and real-time monitoring of Au nanoparticle promoted cancer metastasis using in vivo flow cytometry.Biomedical optics express · 2021Article
- In vitro optoacoustic flow cytometry with light scattering referencing.Scientific reports · 2021Article
- Detection of Apoptotic Circulating Tumor Cells Using in vivo Fluorescence Flow Cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2019Article
- Absorption spectra of nanodiamond aqueous dispersions by optical absorption and optoacoustic spectroscopies.Photoacoustics · 2018Article
- Dynamic blood flow phantom with negative and positive photoacoustic contrasts.Biomedical optics express · 2018Article
- Fluorescence detection, enumeration and characterization of single circulating cells in vivo: technology, applications and future prospects.Physics in medicine and biology · 2017Article
- In vivo noninvasive analysis of graphene nanomaterial pharmacokinetics using photoacoustic flow cytometry.Journal of applied toxicology : JAT · 2017Article
- Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry.Biochemical and biophysical research communications · 2017Article
- PhotoacousticPhotoacoustics · 2017Article
- Gold Nanoparticle Based Platforms for Circulating Cancer Marker Detection.Nanotheranostics · 2017Article
- Article
- Photoacoustic Flow Cytometry for Single Sickle Cell DetectionAnalytical cellular pathology (Amsterdam) · 2016Article
- Isolation of Circulating Melanoma Cells.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Photothermal confocal multicolor microscopy of nanoparticles and nanodrugs in live cells.Drug metabolism reviews · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
In vivo photoacoustic (PA) and fluorescence flow cytometry were previously applied separately using pulsed and continuous wave lasers respectively, and positive contrast detection mode only. This paper introduces a real-time integration of both techniques with positive and negative contrast modes using only pulsed lasers. Various applications of this new tool are summarized, including detection of liposomes loaded with Alexa-660 dye, red blood cells labeled with Indocyanine Green, B16F10 melanoma cells co-expressing melanin and green fluorescent protein (GFP), C8161-GFP melanoma cells targeted by magnetic nanoparticles, MTLn3 adenocarcinoma cells expressing novel near-infrared iRFP protein, and quantum dot-carbon nanotube conjugates. Negative contrast flow cytometry provided label-free detection of low absorbing or weakly fluorescent cells in blood absorption and autofluorescence background, respectively. The use of pulsed laser for time-resolved discrimination of objects with long fluorescence lifetime (e.g., quantum dots) from shorter autofluorescence background (e.g., blood plasma) is also highlighted in this paper. The supplementary nature of PA and fluorescence detection increased the versatility of the integrated method for simultaneous detection of probes and cells having various absorbing and fluorescent properties, and provided verification of PA data using a more established fluorescence based technique.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.