ReviewSleep & breathing = Schlaf & Atmung2014
Obstructive sleep apnea and dyslipidemia: evidence and underlying mechanism.
Review in Sleep & breathing = Schlaf & Atmung, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 2 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Snoring Is Associated With Increased Risk of Stroke: A Cumulative Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Pooled it
- Screening for High Risk of Sleep Apnea in an Ambulatory Care Setting in Saudi Arabia.International journal of environmental research and public health · 2019Trial
- Association between obstructive sleep apnea and albuminuria in Korean adults: a nationwide populationbased study.Kidney research and clinical practice · 2026Article
- Mild Cognitive Impairment Associated with Obstructive Sleep Apnoea: A Pilot Study on Oxygen-Related Plasma Biomarkers and Network Analysis.Molecular neurobiology · 2026Article
- Mechanisms Linking Sleep-Disordered Breathing and Cardiometabolic Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- The Association of Remnant Cholesterol with Obstructive Sleep Apnea and Coronary Heart Disease: A Cross-Sectional Study.Vascular health and risk management · 2026Article
- Article
- STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines.Respiratory research · 2025Article
- Elevated remnant cholesterol impairs sleep characteristics in individuals with newly diagnosed moderate-to-severe obstructive sleep apnea: a cross-sectional case-control study.Frontiers in neurology · 2025Article
- Association between sleep apnea-specific novel hypoxic metrics and disturbances in glucose and lipid metabolism.Frontiers in endocrinology · 2025Article
- Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and atherogenic index of plasma with obstructive sleep apnea.Frontiers in psychiatry · 2025Article
- Association between obstructive sleep apnea risk and atherosclerosis: A nationwide cross-sectional study in the Korean population.PloS one · 2025Article
- Relationships between apolipoprotein E and insulin resistance in patients with obstructive sleep apnoea: a large-scale cross-sectional study.Nutrition & metabolism · 2024Article
- Body mass index mediates the association between plasma lipid concentrations and the prevalence of obstructive sleep apnea among US adults: a cross-sectional study.Frontiers in cardiovascular medicine · 2024Article
- A Prediction Nomogram of Severe Obstructive Sleep Apnea in Patients with Obesity Based on the Liver Stiffness and Abdominal Visceral Adipose Tissue Quantification.Nature and science of sleep · 2024Article
- Article
- Triglyceride-glucose index as a predictor of obstructive sleep apnoea severity in the absence of traditional risk factors.Arquivos de neuro-psiquiatria · 2023Article
- Relationship between slow-wave sleep and serum γ-glutamine transaminase in non-obese men with obstructive sleep apnea-hypopnea syndrome.Sleep & breathing = Schlaf & Atmung · 2023Article
- Association between nontraditional lipid profiles and the severity of obstructive sleep apnea: A retrospective study.Journal of clinical laboratory analysis · 2023Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionOver the past half century, evidence has been accumulating on the emergence of obstructive sleep apnea (OSA), the most prevalent sleep-disordered breathing, as a major risk factor for cardiovascular disease. A significant body of research has been focused on elucidating the complex interplay between OSA and cardiovascular risk factors, including dyslipidemia, obesity, hypertension, and diabetes mellitus that portend increased morbidity and mortality in susceptible individuals.
conclusionAlthough a clear causal relationship of OSA and dyslipidemia is yet to be demonstrated, there is increasing evidence that chronic intermittent hypoxia, a major component of OSA, is independently associated and possibly the root cause of the dyslipidemia via the generation of stearoyl-coenzyme A desaturase-1 and reactive oxygen species, peroxidation of lipids, and sympathetic system dysfunction. The aim of this review is to highlight the relationship between OSA and dyslipidemia in the development of atherosclerosis and present the pathophysiologic mechanisms linking its association to clinical disease. Issues relating to epidemiology, confounding factors, significant gaps in research and future directions are also discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.