ReviewHippocampus2012
Dual functions of perirhinal cortex in fear conditioning.
Review in Hippocampus, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Reduced MOV10 reveals novel functional cortical connections in an increased fear response.bioRxiv : the preprint server for biology · 2026Article
- Dual projecting cells linking thalamic and cortical communication routes between the medial prefrontal cortex and hippocampus.Neurobiology of learning and memory · 2022Article
- Beyond the hippocampus: The role of parahippocampal-prefrontal communication in context-modulated behavior.Neurobiology of learning and memory · 2021Review
- Gamma Oscillations in the Basolateral Amygdala: Localization, Microcircuitry, and Behavioral Correlates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Reconciling the object and spatial processing views of the perirhinal cortex through task-relevant unitization.Hippocampus · 2021Review
- Article
- The hippocampus, prefrontal cortex, and perirhinal cortex are critical to incidental order memory.Behavioural brain research · 2020Article
- Trace Fear Conditioning: Procedure for Assessing Complex Hippocampal Function in Mice.Bio-protocol · 2018Article
- Neonatal perirhinal cortex lesions impair monkeys' ability to modulate their emotional responses.Behavioral neuroscience · 2017Article
- Perirhinal firing patterns are sustained across large spatial segments of the task environment.Nature communications · 2017Article
- Medial temporal pathways for contextual learning: Network c-Brain and neuroscience advances · 2017Article
- Impaired Fear Extinction Due to a Deficit in CaFrontiers in integrative neuroscience · 2017Article
- The role of basal forebrain cholinergic neurons in fear and extinction memory.Neurobiology of learning and memory · 2016Review
- Subcortical connections of the perirhinal, postrhinal, and entorhinal cortices of the rat. II. efferents.Hippocampus · 2016Article
- The role of brain interleukin-1 in stress-enhanced fear learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Bridging the interval: theory and neurobiology of trace conditioning.Behavioural processes · 2014Review
- BDNF-dependent consolidation of fear memories in the perirhinal cortex.Frontiers in behavioral neuroscience · 2013Article
- A review of the neural and behavioral consequences for unitizing emotional and neutral information.Frontiers in behavioral neuroscience · 2013Article
- Article
- Layer V perirhinal cortical ensemble activity during object exploration: a comparison between young and aged rats.Hippocampus · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The present review examines the role of perirhinal cortex (PRC) in Pavlovian fear conditioning. The focus is on rats, partly because so much is known, behaviorally and neurobiologically, about fear conditioning in these animals. In addition, the neuroanatomy and neurophysiology of rat PRC have been described in considerable detail at the cellular and systems levels. The evidence suggests that PRC can serve at least two types of mnemonic functions in Pavlovian fear conditioning. The first function, termed "stimulus unitization," refers to the ability to treat two or more separate items or stimulus elements as a single entity. Supporting evidence for this perceptual function comes from studies of context conditioning as well as delay conditioning to discontinuous auditory cues. In a delay paradigm, the conditional stimulus (CS) and unconditional stimulus (US) overlap temporally and co-terminate. The second PRC function entails a type of "transient memory." Supporting evidence comes from studies of trace cue conditioning, where there is a temporal gap or trace interval between the CS offset and the US onset. For learning to occur, there must be a transient CS representation during the trace interval. We advance a novel neurophysiological mechanism for this transient representation. These two hypothesized functions of PRC are consistent with inferences based on non-aversive forms of learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.