SynthesisBrain imaging and behavior2013
Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.
Synthesis in Brain imaging and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Meta-analysis of SNP-environment interaction with heterogeneity for overlapping data.Scientific reports · 2021Pooled it
- Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.Circulation. Cardiovascular genetics · 2017Pooled it
- Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.Brain imaging and behavior · 2014Pooled it
- The Association Between Lentiform Nucleus Function and Cognitive Impairments in Schizophrenia.Frontiers in human neuroscience · 2021Article
- Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits.Nature genetics · 2019Article
- Increasing the power of meta-analysis of genome-wide association studies to detect heterogeneous effects.Bioinformatics (Oxford, England) · 2017Article
- Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes.The Journal of biological chemistry · 2017Review
- Genome-wide association study of paliperidone efficacy.Pharmacogenetics and genomics · 2017Article
- Toward an integrative science of the developing human mind and brain: Focus on the developing cortex.Developmental cognitive neuroscience · 2016Article
- The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.Neurobiology of aging · 2016Article
- The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.Genome biology · 2015Article
- 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- Altered regional brain volumes in elderly carriers of a risk variant for drug abuse in the dopamine D2 receptor gene (DRD2).Brain imaging and behavior · 2015Article
- Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations.Scientific reports · 2015Article
- Genetics and brain morphology.Neuropsychology review · 2015Article
- The perfect neuroimaging-genetics-computation storm: collision of petabytes of data, millions of hardware devices and thousands of software tools.Brain imaging and behavior · 2014Article
- The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.Brain imaging and behavior · 2014Review
- The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013Review
- A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly.Frontiers in aging neuroscience · 2013Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
Abstract
Deficits in lentiform nucleus volume and morphometry are implicated in a number of genetically influenced disorders, including Parkinson's disease, schizophrenia, and ADHD. Here we performed genome-wide searches to discover common genetic variants associated with differences in lentiform nucleus volume in human populations. We assessed structural MRI scans of the brain in two large genotyped samples: the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 706) and the Queensland Twin Imaging Study (QTIM; N = 639). Statistics of association from each cohort were combined meta-analytically using a fixed-effects model to boost power and to reduce the prevalence of false positive findings. We identified a number of associations in and around the flavin-containing monooxygenase (FMO) gene cluster. The most highly associated SNP, rs1795240, was located in the FMO3 gene; after meta-analysis, it showed genome-wide significant evidence of association with lentiform nucleus volume (P MA = 4.79 × 10(-8)). This commonly-carried genetic variant accounted for 2.68 % and 0.84 % of the trait variability in the ADNI and QTIM samples, respectively, even though the QTIM sample was on average 50 years younger. Pathway enrichment analysis revealed significant contributions of this gene to the cytochrome P450 pathway, which is involved in metabolizing numerous therapeutic drugs for pain, seizures, mania, depression, anxiety, and psychosis. The genetic variants we identified provide replicated, genome-wide significant evidence for the FMO gene cluster's involvement in lentiform nucleus volume differences in human populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.