ArticlePsychopharmacology2012
The effect of environmental factors on morphine withdrawal in C57BL/6J mice: running wheel access and group housing.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Neuronal apoptosis induced by morphine withdrawal is mediated by the p75 neurotrophin receptor.Journal of neurochemistry · 2021Article
- Incubation of Oxycodone Craving Following Adult-Onset and Adolescent-Onset Oxycodone Self-Administration in Male Rats.Frontiers in behavioral neuroscience · 2021Article
- Effects of voluntary exercise and sex on multiply-triggered heroin reinstatement in male and female rats.Psychopharmacology · 2020Article
- Running in the wheel: Defining individual severity levels in mice.PLoS biology · 2018Article
- Wheel running during chronic nicotine exposure is protective against mecamylamine-precipitated withdrawal and up-regulates hippocampal α7 nACh receptors in mice.British journal of pharmacology · 2018Article
- Exercise as a Sex-Specific Treatment for Substance Use Disorder.Current addiction reports · 2017Article
- Physical Exercise Interventions for Drug Addictive Disorders.Journal of reward deficiency syndrome and addiction science · 2017Article
- The adenosinergic system is involved in sensitization to morphine withdrawal signs in rats-neurochemical and molecular basis in dopaminergic system.Psychopharmacology · 2016Article
- Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis.Neuroscience and biobehavioral reviews · 2013Review
- Thermal sensitivity as a measure of spontaneous morphine withdrawal in mice.Journal of pharmacological and toxicological methodsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThere is evidence to suggest that the rewarding effects of drugs of abuse can be altered by environmental manipulations such as housing conditions and access to running wheels. There is less information about how these environmental manipulations alter withdrawal behaviors following the termination of chronic drug administration.
objectivesThe objective of this study is to examine the effects of access to running wheels and group housing on spontaneous morphine withdrawal.
methodsC57BL/6J mice were assigned to one of the three housing conditions: wheel access (singly housed), no wheels (singly housed), or group-housed (no wheels). Mice received 30 or 56 mg/kg morphine or saline (s.c.) twice daily for 5.5 days. At baseline and at 8, 24, 32, and 48 h following the final injection, latency to respond on a hot plate was determined across a range of temperatures (50, 52, 54, and 56 °C).
resultsLatency to respond decreased as a function of temperature. Response latencies during the withdrawal period were decreased in mice without wheel access treated with both 30 and 56 mg/kg of morphine. This increase in thermal sensitivity was significantly attenuated in singly housed mice with wheel access and in group-housed mice; however, the effects were less pronounced in the group-housed mice and depended upon the time during withdrawal.
conclusionsBoth wheel access and group housing attenuate the increase in thermal sensitivity seen in morphine-treated mice during morphine withdrawal.
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