ArticleEuropean journal of pediatrics2012
Familial Mediterranean fever in Germany: epidemiological, clinical, and genetic characteristics of a pediatric population.
Article in European journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Late-onset-case of Familial Mediterranean fever (FMF)-exotic but rising differential diagnosis of "unclear abdominal illness" in Germany due to increasing migration over the past decade.Wiener medizinische Wochenschrift (1946) · 2026Article
- [Use of IL-1 inhibitors in the treatment of familial Mediterranean fever in pediatric rheumatology].Zeitschrift fur Rheumatologie · 2025Article
- Treat-to-target strategies for the management of familial Mediterranean Fever in children.Pediatric rheumatology online journal · 2023Article
- Familial Mediterranean Fever in Spain: Time Trend and Spatial Distribution of the Hospitalizations.International journal of environmental research and public health · 2023Article
- The Preferential Use of Anakinra in Various Settings of FMF: A Review Applied to an Updated Treatment-Related Perspective of the Disease.International journal of molecular sciences · 2022Review
- [Clinical symptoms of autoinflammatory diseases].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2020Review
- State of care for patients with systemic autoinflammatory diseases - Results of a tertiary care survey.The World Allergy Organization journal · 2019Article
- The patient journey to diagnosis and treatment of autoinflammatory diseases.Orphanet journal of rare diseases · 2018Article
- Familial Mediterranean fever presenting as fever of unknown origin in Korea.Korean journal of pediatrics · 2016Article
- P wave dispersion and QT dispersion in adult Turkish migrants with familial mediterranean fever living in Germany.International journal of medical sciences · 2014Article
- [Self-medication to treat pain in attacks of familial Mediterranean fever: aiming to find a new approach to pain management].Schmerz (Berlin, Germany) · 2013Article
- Autoinflammatory syndromes.Dermatologic clinics · 2013Review
- [Genetic fever syndromes. Hereditary recurrent (periodic) fever syndromes].Zeitschrift fur Rheumatologie · 2013Article
- [Interleukin-1-mediated diseases].Der Internist · 2013Article
- Clinical genetic testing of periodic fever syndromes.BioMed research international · 2013Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledFamilial Mediterranean fever (FMF) is an autoinflammatory disease and belongs to the heterogeneous group of hereditary recurrent fever syndromes (HRFs).
aimsThe aims of the study were to determine the incidence of FMF in Germany and to describe the spectrum of pyrin mutations and the clinical characteristics in children. A prospective surveillance of children with HRF including FMF was conducted in Germany during a time period of 3 years by the German paediatric surveillance unit for rare paediatric diseases (ESPED). Monthly inquiries were sent to 370 children's hospitals (Clinic-ESPED, n1) and to 23 laboratories (Laboratory-ESPED, n2). Inclusion criteria were children ≤ 16 years of age, disease-associated pyrin mutations, and more than three self-limiting episodes of fever >38.5 °C with increased inflammation markers. In n1, 122 patients with FMF and 225 pyrin mutations were identified. Ninety-two of 122 (75 %) children were of Turkish origin. The minimum incidence of FMF was estimated to be 3 (95 % CI: 2.48-3.54) per 10(6) person-years in the whole children population and 55 (95 % CI: 46-66) per 10(6) person-years in Turkish children living in Germany. N1 U n2 amounted to 593 asymptomatic and symptomatic carriers of 895 mutations (overlap of 73 cases with 134 mutations). p.Met694Val (45 %), p.Met680Ile (14 %), p.Val726Ala (12 %), and p.Glu148Gln (11.5 %) were the most common pyrin mutations.
conclusionsDespite FMF being the most frequent of the HRFs, its incidence in Germany is low. Twenty-five to 50 FMF patients ≤ 16 years are newly diagnosed per year. The disease is most commonly observed in individuals of Turkish ancestry.
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