ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2012
Pediatric glioblastoma: clinico-radiological profile and factors affecting the outcome.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 60 citations in OpenAlex.
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- Comprehensive characterization and targeted treatment of a pediatric epithelioid glioblastoma with a rare TRIM24-NTRK2 fusion.NPJ precision oncology · 2025Article
- Long-Term Outcomes of Radiation Therapy for Pediatric Brain Tumors: A Single-Center Study.Cureus · 2025Article
- Glioblastoma stem cell metabolism and immunity.Cancer metastasis reviews · 2024Review
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- Pediatric extra-axial glioblastoma with bone invasion leading to a subcutaneous mass: A case report.Surgical neurology international · 2024Article
- Myeloid cells as potential targets for immunotherapy in pediatric gliomas.Frontiers in pediatrics · 2024Review
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- Novel Pharmacological Treatment Options in Pediatric Glioblastoma-A Systematic Review.Cancers · 2022Review
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- Primary cerebellar glioblastomas in children: clinical presentation and management.Neurosurgical review · 2021Article
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- Advanced Magnetic Resonance Imaging in Pediatric Glioblastomas.Frontiers in neurology · 2021Review
- Pediatric Giant Cell Glioblastoma Presenting with Intracranial Dissemination at Diagnosis: A Case Report.NMC case report journal · 2021Article
- AB Blood Group Confers Higher Risk for Primary Brain Tumors in Pediatrics.Risk management and healthcare policy · 2021Article
- Paraneoplastic Ophthalmoplegia as the Presenting Sign of Paediatric Glioblastoma Multiforme: A Case Report.Neuro-ophthalmology (Aeolus Press) · 2021Article
- Glioblastoma multiforme misdiagnosed as squint: A case report.Journal of family medicine and primary care · 2020Article
- Musashi1 enhances chemotherapy resistance of pediatric glioblastoma cells in vitro.Pediatric research · 2020Article
- H3K27M, IDH1, and ATRX expression in pediatric GBM and their clinical and prognostic significance.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
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7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeGlioblastoma in the pediatric age group is relatively rare. As a result, it has been difficult to deduce any consistent clinico-radiological and pathological profiles on these patients. Also, the prognostic factors affecting the survival in pediatric glioblastoma are not as well defined as in adults. PATIENTS AND
methodsIn this retrospective series, 65 pediatric patients (age ≤ 18 years) from January 1995 to December 2011 with histopathologically proven diagnosis of intracranial glioblastoma were studied. Clinico-radiological, pathological, treatment, and follow-up data were collected. Progression-free and overall survivals were assessed using the Kaplan-Meier method.
resultsThe male-to-female ratio was 2.6:1 with a mean age of 13.29 ± 4.53 years (range 2-18 years). Headache with or without vomiting (n = 51, 78 %), followed by seizures (n = 42, 65 %), and focal deficits (n = 31, 47 %) were the leading symptoms. Forty-nine (75 %) patients had tumors located superficially, whereas there were 16 patients with deeply located glioblastomas (25 %). Gross total tumor excision was achieved in 43 (66 %) patients, while the remaining patients had incomplete excision (n = 22, 34 %). Mean follow-up was 17.7 months (range 1.5-119 months). The median progression-free and overall survivals were 10 and 20 months, respectively. Extent of resection was found to be the independent predictor of survival (p value = 0.002).
conclusionPediatric glioblastomas are associated with longer progression-free as well as overall survivals. Extent of tumor resection is the strongest predictor of survival in pediatric glioblastoma. Hence, an aggressive surgical resection may fetch a better outcome in children with glioblastoma.
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