Trial reportClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2013
Relationship between detection of adenomas by flexible sigmoidoscopy and interval distal colorectal cancer.
Trial report in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Higher Adenoma Detection Rates at Screening Associated With Lower Long-Term Colorectal Cancer Incidence and Mortality.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Trial
- Quality indicators in colonoscopy: observational study in a supplementary health system.Acta cirurgica brasileira · 2023Observational
- Interval Colorectal Cancer 2006-2015: Novel Observations.Digestive diseases and sciences · 2021Article
- Index colonoscopy-related risk factors for postcolonoscopy colorectal cancers.Gastrointestinal endoscopy · 2019Article
- Incidence of interval colorectal cancer attributable to an endoscopist in clinical practice.Gastrointestinal endoscopy · 2018Article
- Variable Endoscopist performance in proximal and distal adenoma detection during colonoscopy: a retrospective cohort study.BMC gastroenterology · 2018Article
- Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) quality improvement initiative.United European gastroenterology journal · 2017Review
- Quality of colonoscopy in an emerging country: A prospective, multicentre study in Russia.United European gastroenterology journal · 2017Article
- Adjusting for patient demographics has minimal effects on rates of adenoma detection in a large, community-based setting.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
- Efficacy and cost-effectiveness of screening colonoscopy according to the adenoma detection rate.United European gastroenterology journal · 2015Article
- Adenoma detection rate in patients younger than 50 years of age: relationship of the adenoma detection rate to interval cancer.Annals of coloproctology · 2015Article
- High-definition white-light (HDWL) colonoscopy and higher adenoma detection rate and the potential for paradoxical over surveillance.Digestive diseases and sciences · 2014Article
- Adenoma detection rate and risk of colorectal cancer and death.The New England journal of medicine · 2014Article
- Colorectal cancer screening--optimizing current strategies and new directions.Nature reviews. Clinical oncology · 2013Review
- Continuous quality improvement of colorectal cancer screening.World journal of gastrointestinal pharmacology and therapeutics · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsLow rates of adenoma detection by colonoscopy have been associated with increased rates of interval colorectal cancer. We evaluated the relationship between the rate of adenoma detection by flexible sigmoidoscopy and interval distal colorectal cancer.
methodsWe analyzed data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer screening trial, which used flexible sigmoidoscopy as a colorectal cancer screening modality (46,835 subjects; 66,711 examinations by 93 examiners). An adenoma detection rate was defined for each examiner as the number of examinations that identified adenomas (confirmed by pathology analysis) divided by the total number of screening examinations. Interval cancers were defined as cancers presumed detectable but not detected, which was based on the stage at diagnosis and the elapsed time from screening to diagnosis.
resultsThe Prostate, Lung, Colorectal, and Ovarian Cancer study identified 32 interval distal cancers. The incidence of interval cancer for individuals screened by examiners in the lowest quartile of distal adenoma detection (2.0%-7.2%) was 9.0/10,000 examinations, whereas the incidence of interval cancers was lower among individuals whose examiners were in higher quartiles of adenoma detection, ranging from 3.0 to 5.4/10,000 examinations. The odds of interval distal cancer were significantly increased for patients of examiners in the lowest quartile of distal adenoma detection (<7.2%), with an adjusted odds ratio of 2.4 (95% confidence interval, 1.1-5.0; P = .02).
conclusionsLower levels of adenoma detection by flexible sigmoidoscopy increase the risk for interval distal cancer. Detection of distal adenomas is a marker of the performance quality of flexible sigmoidoscopy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.