Evidence map›Paper›PMID 22902050›Full record

ArticleLeukemia research2012

Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma.

Anthony M D'Amelio, Claudia Monroy, Randa El-Zein, Carol J Etzel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. The Role of DNA Repair (Medicina (Kaunas, Lithuania) · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anthony M D'AmelioThe University of Texas Graduate School for Biomedical Sciences, Houston, TX 77030, United States.
Claudia Monroy
Randa El-Zein
Carol J Etzel
The University of Texas MD Anderson Cancer Center · US

Funding

Chromosomal Aberrations and Risk for Familial Lung CancerR01CA123208 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ETZEL, CAROL J · 2006 to 2009
$1.1M
Risk models:environment versus metabolic polymorphismsK07CA093592 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ETZEL, CAROL J · 2003 to 2007
$679k
NCI NIH HHS CA123NCI NIH HHS K07 CA093592NCI NIH HHS K07CA093592NCI NIH HHS R01 CA123208
6 · The paper itself

Abstract

In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with haplotype CT (rs2228001 and rs2228000), and a protective association was observed on the IL4R gene with haplotype TCA (rs1805012, rs1805015, and rs1801275). These results can provide the necessary tools to identify high-risk individuals after validation in large data sets.

Indexed as

DNA-Binding ProteinsFemaleGenetic Predisposition to DiseaseHaplotypesHodgkin DiseaseHumansInterleukin-4 Receptor alpha SubunitMaleMiddle AgedPolymorphism, Single NucleotideDNA-Binding ProteinsIL4R protein, humanInterleukin-4 Receptor alpha SubunitXPC protein, human

Identifiers

PMID22902050
PMCPMC3449215
OpenAlexW2048015642

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.