ReviewDental materials : official publication of the Academy of Dental Materials2013
Optimizing dentin bond durability: control of collagen degradation by matrix metalloproteinases and cysteine cathepsins.
Review in Dental materials : official publication of the Academy of Dental Materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
148 citing papers in PubMed, 5 syntheses or guidelines pooled it, 517 citations in OpenAlex.
- Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Pooled it
- Effect of collagen cross-linkers on dentin bond strength: A systematic review and network meta-analysis.Frontiers in bioengineering and biotechnology · 2022Pooled it
- MMP Inhibitors on Dentin Stability: A Systematic Review and Meta-analysis.Journal of dental research · 2014Pooled it
- Mechanisms regulating the degradation of dentin matrices by endogenous dentin proteases and their role in dental adhesion. A review.American journal of dentistry · 2014Pooled it
- 6-Month Clinical Evaluation of Reduced Dentin Etching Time Using Universal Adhesives in Noncarious Cervical Lesions: A Double-Blind Randomized Clinical Trial.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Trial
- Trial
- Clinical, radiographic and biochemical assessment of proximal cavities restored with composite resin using incremental vs. bulk packing techniques: One-year randomized clinical trial.BMC oral health · 2024Trial
- Inactivation of matrix-bound matrix metalloproteinases by cross-linking agents in acid-etched dentin.Operative dentistryTrial
- In Vitro Evaluation of Bond Strength of Adhesive Systems to Dentin and Stability of the Hybrid Layer.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Article
- Applications of Nanomaterials in Restorative Dentistry and Endodontics: A Narrative Review.Materials (Basel, Switzerland) · 2026Review
- Remineralization Effect of a Strontium-Containing Composite: An In Vitro Study.Materials (Basel, Switzerland) · 2026Article
- Influence of Different Cavity Disinfection Protocols on Adhesion at the Resin Composite-Dentin Interface.Polymers · 2026Article
- Biomimetic Design of Dental Restorative Materials: Conceptual Framework and Translational Challenges.Biomimetics (Basel, Switzerland) · 2026Review
- A novel dual-reactive primer enhances bond durability and builds chemical interlocking structures at the caries-affected dentin-biomaterial interface.Materials today. Bio · 2026Article
- Balancing Demineralisation and Collagen Integrity: A Nanoscale Analysis of Etching Time in Human Dentin.International dental journal · 2026Article
- Development of multifunctional dental adhesive with 4-formylphenyl acrylate and nano-silver.Clinical oral investigations · 2026Article
- Bond strength and interfacial stability of a universal adhesive to alendronate-treated dentin.Scientific reports · 2026Article
- Effect of ammonia-free silver fluoride application on the resin-dentin interface subjected to an in situ cariogenic challenge.Clinical oral investigations · 2026Article
- Effects of ZnO/Cu and bioactive glass-modified universal adhesives on biological properties, bond strength, and interfacial stability under cariogenic challenge.Clinical oral investigations · 2026Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 5 countries.
Funding
Abstract
objectivesContemporary adhesives lose their bond strength to dentin regardless of the bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid layers. The preservation of the collagen matrix integrity is a key issue in the attempts to improve the dentin bonding durability.
methodsDentin contains collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins, which are responsible for the hydrolytic degradation of collagen matrix in the bonded interface.
resultsThe identities, roles and function of collagenolytic enzymes in mineralized dentin has been gathered only within last 15 years, but they have already been demonstrated to have an important role in dental hard tissue pathologies, including the degradation of the hybrid layer. Identifying responsible enzymes facilitates the development of new, more efficient methods to improve the stability of dentin-adhesive bond and durability of bond strength. SIGNIFICANCE: Understanding the nature and role of proteolytic degradation of dentin-adhesive interfaces has improved immensely and has practically grown to a scientific field of its own within only 10 years, holding excellent promise that stable resin-dentin bonds will be routinely available in a daily clinical setting already in a near future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.