ArticleBiology of mood & anxiety disorders2012
Somatic therapies for treatment-resistant depression: ECT, TMS, VNS, DBS.
Article in Biology of mood & anxiety disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07097025 (Efficacy and Safety of Vagus Nerve Stimulation Treatment in Treatment Resistant Depression), which is not on this map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Vagus Nerve Stimulation Treatment in Treatment Resistant Depression
Who cites it
33 citing papers in PubMed.
- Mental Health Parity in Interventional Psychiatry: Access, Ethical and Policy Implications.Current psychiatry reports · 2026Review
- Depression Treatment: Is There a Role for Botulinum Toxin Type A?Microorganisms · 2024Review
- The future of brain circuit-targeted therapeutics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Repetitive Transcranial Magnetic Stimulation With and Without Text4Support for the Treatment of Resistant Depression: Protocol for a Patient-Centered Multicenter Randomized Controlled Pilot Trial.JMIR research protocols · 2023Article
- Current and future directions of drug delivery for the treatment of mental illnesses.Advanced drug delivery reviews · 2023Review
- Article
- Effects of electroconvulsive therapy on cerebral AFrontiers in psychiatry · 2023Article
- Annual costs among patients with major depressive disorder and the impact of key clinical events.Journal of managed care & specialty pharmacy · 2022Article
- Response to TMS treatment for depression associated with higher levels of psychological well-being.Journal of psychiatric research · 2022Article
- Improved Safety of Hybrid Electroconvulsive Therapy Compared With Standard Electroconvulsive Therapy in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Parallel-Group Pilot Trial.Frontiers in psychiatry · 2022Article
- Transcutaneous Electrical Cranial-Auricular Acupoint Stimulation vs. Escitalopram for Patients With Mild-to-Moderate Depression (TECAS): Study Design for a Randomized Controlled, Non-inferiority Trial.Frontiers in psychiatry · 2022Article
- Implications from translational cross-validation of clinical assessment tools for diagnosis and treatment in psychiatry.World journal of psychiatry · 2021Review
- Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy.Frontiers in psychiatry · 2020Article
- Evaluation and comparison of the antidepressant-like activity ofResearch in pharmaceutical sciences · 2019Article
- Article
- Low-Charge Electrotherapy in Geriatric Major Depressive Disorder Patients: A Case Series.Psychiatry investigation · 2019Article
- Prognosis and improved outcomes in major depression: a review.Translational psychiatry · 2019Review
- Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up.Neuropsychiatric disease and treatment · 2019Article
- Buprenorphine/samidorphan combination for the adjunctive treatment of major depressive disorder: results of a phase III clinical trial (FORWARD-3).Neuropsychiatric disease and treatment · 2019Article
- Patients with depression who self-refer for transcranial magnetic stimulation treatment: exploratory qualitative study.BJPsych bulletin · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of non-pharmacological therapies for treatment resistant depression (TRD) is rapidly evolving and new somatic therapies are valuable options for patients who have failed numerous other treatments. A major challenge for clinicians (and patients alike) is how to integrate the results from published clinical trials in the clinical decision-making process.We reviewed the literature for articles reporting results for clinical trials in particular efficacy data, contraindications and side effects of somatic therapies including electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), vagal nerve stimulation (VNS) and deep brain stimulation (DBS). Each of these devices has an indication for patients with different level of treatment resistance, based on acuteness of illness, likelihood of response, costs and associated risks. ECT is widely available and its effects are relatively rapid in severe TRD, but its cognitive adverse effects may be cumbersome. TMS is safe and well tolerated, and it has been approved by FDA for adults who have failed to respond to one antidepressant, but its use in TRD is still controversial as it is not supported by rigorous double-blind randomized clinical trials. The options requiring surgical approach are VNS and DBS. VNS has been FDA-approved for TRD, however it is not indicated for management of acute illness. DBS for TRD is still an experimental area of investigation and double-blind clinical trials are underway.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.