ArticleFEMS microbiology letters2012
A novel function for the competence inducing peptide, XIP, as a cell death effector of Streptococcus mutans.
Article in FEMS microbiology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 49 citations in OpenAlex.
- ComprehensiveFrontiers in microbiology · 2024Article
- Transposon mutagenesis in oralJournal of oral microbiology · 2022Review
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- The dental plaque biofilm matrix.Periodontology 2000 · 2021Review
- Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans.Nature microbiology · 2021Article
- Understanding the Matrix: The Role of Extracellular DNA in Oral Biofilms.Frontiers in oral health · 2021Review
- Competence-Stimulating-Peptide-Dependent Localized Cell Death and Extracellular DNA Production in Streptococcus mutans Biofilms.Applied and environmental microbiology · 2020Article
- Molecular dissection of pheromone selectivity in the competence signaling system ComRS of streptococci.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Biofilm Formation by Streptococcus mutans is Enhanced by Indole via the Quorum Sensing Pathway.Microbes and environments · 2020Article
- Glycosyltransferase-Mediated Biofilm Matrix Dynamics and Virulence of Streptococcus mutans.Applied and environmental microbiology · 2019Article
- Conserved Pheromone Production, Response and Degradation byFrontiers in microbiology · 2019Article
- Expanding the Vocabulary of Peptide Signals inFrontiers in cellular and infection microbiology · 2019Review
- Intracellular Signaling by themSphere · 2018Article
- Competence inhibition by the XrpA peptide encoded within the comX gene of Streptococcus mutans.Molecular microbiology · 2018Article
- Genome-Wide Screens Reveal New Gene Products That Influence Genetic Competence in Streptococcus mutans.Journal of bacteriology · 2018Article
- Intercellular Communication via theJournal of bacteriology · 2017Article
- Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model.Molecular oral microbiology · 2017Article
- Functional amyloids in Streptococcus mutans, their use as targets of biofilm inhibition and initial characterization of SMU_63c.Microbiology (Reading, England) · 2017Article
- Origins of heterogeneity in Streptococcus mutans competence: interpreting an environment-sensitive signaling pathway.Physical biology · 2017Article
- Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS.PLoS pathogens · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
In Streptococcus mutans, ComX, an alternative sigma factor, drives the transcription of the 'late-competence genes' required for genetic transformation. ComX activity is modulated by inputs from two signaling pathways, ComDE and ComRS, that respond to the competence-stimulating peptide (CSP) and the SigX-inducing peptide (XIP), respectively. In particular, the comRS, encoding the ComR regulatory protein and the ComS precursor to XIP, functions as the proximal regulatory system for ComX activation. Here, we investigated the individual and combinatorial effects of CSP and XIP on genetic transformation and cell killing of S. mutans. Our transformation results confirm the recent reports by Mashburn-Warren et al. and Desai et al. that XIP functions optimally in a chemically defined medium, whereas its activity is inhibited when cells are grown in complex medium. Using tandem mass spectrometry (MS/MS) fragmentation, a drastic reduction in XIP levels in ComX-deficient cultures were observed, suggesting a ComX-mediated positive feedback mechanism for XIP synthesis. Our evaluation of cell viability in the presence of 10 μM XIP resulted in killing nearly 82% of the population. The killing activity was shown to be dependent on the presence of comR/S and comX. These results suggest a novel role for XIP as a compelling effector of cell death. This is the first report that demonstrates a role for XIP in cell killing.
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