Evidence map›Paper›PMID 22900542›Full record

ArticleThe journal of physical chemistry. B2012

Stable, compact, bright biofunctional quantum dots with improved peptide coating.

Jianmin Xu, Piotr Ruchala, Yuval Ebenstain, J Jack Li, Shimon Weiss

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Structural Design of Multidentate Copolymers as Compact Quantum Dot Coatings for Live-Cell Single-Particle Imaging.Chemistry of materials : a publication of the American Chemical Society · 2022
    Article
  3. Antibody Self-Assembly Maximizes Cytoplasmic Immunostaining Accuracy of Compact Quantum Dots.Chemistry of materials : a publication of the American Chemical Society · 2021
    Article
  4. Peptide-Enabled Targeted Delivery Systems for Therapeutic Applications.Frontiers in bioengineering and biotechnology · 2021
    Review
  5. Somatostatin receptors as a new active targeting sites for nanoparticles.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Review
  6. Review
  7. Article
  8. Somatostatin Decorated Quantum Dots for Targeting of Somatostatin Receptors.Iranian journal of pharmaceutical research : IJPR · 2018
    Article
  9. Nanotechnology applications in thoracic surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2016
    Review
  10. Article
  11. Brightness-equalized quantum dots.Nature communications · 2015
    Article
  12. Article
  13. Article
  14. Review
  15. Labeling Cytosolic Targets in Live Cells with Blinking Probes.The journal of physical chemistry letters · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jianmin XuDepartment of Chemistry & Biochemistry, University of California at Los Angeles, Los Angeles, California 90095, USA.
Piotr Ruchala
Yuval Ebenstain
J Jack Li
Shimon Weiss
California NanoSystems Institute · USUniversity of California, Los Angeles · US

Funding

New Probe and Methods for Correlated LM & EMR01GM086197 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ADAMS, STEPHEN ROY, BOASSA, DANIELA · 2008 to 2020
$8.3M
Multimodal Qdot Probes for Bioimaging of Cells and Tumors in Small AnimalsR01EB000312 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, SHIMON · 2002 to 2010
$7.5M
DEVELOPMENT OF Q-DOTS AS BIOLOGICAL PROBESR01RR014891 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, SHIMON · 2000 to 2001
$2.4M
NCRR NIH HHS R01 RR014891NIBIB NIH HHS 5R01EB000312NIBIB NIH HHS R01 EB000312NIGMS NIH HHS 1R01GM086197NIGMS NIH HHS R01 GM086197
6 · The paper itself

Abstract

We developed a new peptide, natural phytochelatin (PC), which tightly binds to CdSe/ZnS quantum dots' (QDs) surfaces and renders them water-soluble. Coating QDs with this flexible and all-hydrophilic peptide offers high colloidal stability, adds only 0.8-0.9 nm to the radius of the particles (as compared to their original inorganic radius), preserves very high quantum yield (QY) in water, and affords facile bioconjugation with various functional groups. We demonstrate specific targeting (with minimal nonspecific binding) of such fluorescein-conjugated QDs to ScFv-fused mouse prion protein expressed in live N2A cells. We also demonstrated homogeneous in vivo biodistribution with no significant toxicity in live zebrafish.

Indexed as

Quantum DotsAnimalsCadmium CompoundsCell Line, TumorMiceMolecular ImagingParticle SizePeptidesSelenium CompoundsSolubilitySulfidesTissue DistributionWaterZebrafishZinc CompoundsCadmium Compoundscadmium selenidePeptidesSelenium CompoundsSulfidesWaterZinc Compoundszinc sulfide

Identifiers

PMID22900542
PMCPMC3470653
OpenAlexW1971847993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.