ArticleISRN neurology2012
Anorectal dysfunction in multiple sclerosis: a systematic review.
Article in ISRN neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- How Can We Treat If We Do Not Measure: A Systematic Review of Neurogenic Bowel Objective Measures.Topics in spinal cord injury rehabilitation · 2024Pooled it
- Lower Urinary Tract Symptoms as an Indicator of Occult Neurologic Disease: A System-first Framework for Urologic Practice.Current urology reports · 2026Review
- Innovative multidisciplinary tool for screening bowel and bladder symptoms in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- The microbiota-gut-brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention.Frontiers in aging neuroscience · 2025Review
- A multiscale assessment of bowel impairment in an Italian multiple sclerosis cohort.Scientific reports · 2023Article
- Pelvic Floor Dysfunctions and Their Rehabilitation in Multiple Sclerosis.Journal of clinical medicine · 2022Review
- Prevalence and predictors of bowel dysfunction in a large multiple sclerosis outpatient population: an Italian multicenter study.Journal of neurology · 2022Article
- Anorectal dysfunction in multiple sclerosis patients: A pilot study on the effect of an individualized rehabilitation approach.NeuroRehabilitation · 2022Article
- Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications.Current neuropharmacology · 2022Review
- Pharmacological Management of Neurogenic Bowel Dysfunction after Spinal Cord Injury and Multiple Sclerosis: A Systematic Review and Clinical Implications.Journal of clinical medicine · 2021Review
- Gastrointestinal and urinary complaints in adults with hereditary spastic paraparesis.Orphanet journal of rare diseases · 2018Article
- Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls.Scientific reports · 2016Article
- Anal sphincter dysfunction in multiple sclerosis: an observation manometric study.Open medicine (Warsaw, Poland) · 2016Article
- Symptomatic management in multiple sclerosis.Annals of Indian Academy of Neurology · 2015Review
- Medical management of fecal incontinence in challenging populations: a review.Clinics in colon and rectal surgery · 2014Review
- A rare condition of anorectal dysfunction in a patient with multiple sclerosis: Coexistence of faecal incontinence and mechanical constipation: Report of case.International journal of surgery case reports · 2014Article
- Hospitalization rates and discharge status in multiple sclerosis.Multiple sclerosis international · 2013Article
- Adding to the burden: gastrointestinal symptoms and syndromes in multiple sclerosis.Multiple sclerosis international · 2013Article
- Technology-assisted toilets: Improving independence and hygiene in stroke rehabilitation.Journal of rehabilitation and assistive technologies engineeringArticle
- Validation of the Dutch-Language Version of the Neurogenic Bowel Dysfunction Score in Patients With Multiple Sclerosis.International journal of MS careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Constipation and fecal incontinence are common in patients with neuromuscular diseases. Despite their high prevalence and potential impact on overall quality of life, few studies have addressed anorectal dysfunction in patients with multiple sclerosis (MS). The goal of this paper is to define the prevalence, pathophysiology, impact, and potential treatment of constipation and incontinence in MS patients. Methods. The PubMed database was searched for English language publications between January 1973 and December 2011. Articles were reviewed to assess the definition of the study population, duration, type and severity of MS, sex distribution, prevalence, impact, results of physiologic testing, and treatments. Results. The reported prevalence of constipation and fecal incontinence ranged around 40%. Anorectal dysfunction significantly affected patients with nearly 1 in 6 patients limiting social activities or even quitting work due to symptoms. Caregivers listed toileting as a common and significant burden. The only randomized controlled trial showed a marginal improvement of constipation with abdominal massage. All other reports lacked control interventions and only demonstrated improvement in individuals with milder symptoms. Conclusion. Anorectal dysfunction is a common manifestation in MS that significantly affects quality of life. Therapies are at best moderately effective and often cumbersome, highlighting the need for simple and more helpful interventions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.