ArticleInternational journal of proteomics2012
A Comprehensive Subcellular Proteomic Survey of Salmonella Grown under Phagosome-Mimicking versus Standard Laboratory Conditions.
Article in International journal of proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Design of a yeast SUMO tag to eliminate internal translation initiation.Protein science : a publication of the Protein Society · 2025Article
- Prediction of Potential Drug Targets and Vaccine Candidates Against Antibiotic-ResistantInternational journal of peptide research and therapeutics · 2022Article
- Salmonella enterica Serovars Dublin and Enteritidis Comparative Proteomics Reveals Differential Expression of Proteins Involved in Stress Resistance, Virulence, and Anaerobic Metabolism.Infection and immunity · 2021Article
- Integrated Use of Biochemical, Native Mass Spectrometry, Computational, and Genome-Editing Methods to Elucidate the Mechanism of a Salmonella deglycase.Journal of molecular biology · 2019Article
- Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity.PLoS neglected tropical diseases · 2019Article
- Salmonella FraE, an Asparaginase Homolog, Contributes to Fructose-Asparagine but Not Asparagine Utilization.Journal of bacteriology · 2017Article
- A metabolic intermediate of the fructose-asparagine utilization pathway inhibits growth of a Salmonella fraB mutant.Scientific reports · 2016Article
- Proteomic Analyses of Intracellular Salmonella enterica Serovar Typhimurium Reveal Extensive Bacterial Adaptations to Infected Host Epithelial Cells.Infection and immunity · 2015Article
- Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions.Protein & cell · 2015Review
- Article
- Identification and characterization of outer membrane vesicle-associated proteins in Salmonella enterica serovar Typhimurium.Infection and immunity · 2014Article
- Complete proteome of a quinolone-resistant Salmonella Typhimurium phage type DT104B clinical strain.International journal of molecular sciences · 2014Article
- Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.PLoS pathogens · 2014Article
- Identification of Protective Antigens for Vaccination against Systemic Salmonellosis.Frontiers in immunology · 2014Review
- Top-down proteomics reveals a unique protein S-thiolation switch in Salmonella Typhimurium in response to infection-like conditions.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Salmonella modulates metabolism during growth under conditions that induce expression of virulence genes.Molecular bioSystems · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Towards developing a systems-level pathobiological understanding of Salmonella enterica, we performed a subcellular proteomic analysis of this pathogen grown under standard laboratory and phagosome-mimicking conditions in vitro. Analysis of proteins from cytoplasmic, inner membrane, periplasmic, and outer membrane fractions yielded coverage of 25% of the theoretical proteome. Confident subcellular location could be assigned to over 1000 proteins, with good agreement between experimentally observed location and predicted/known protein properties. Comparison of protein location under the different environmental conditions provided insight into dynamic protein localization and possible moonlighting (multiple function) activities. Notable examples of dynamic localization were the response regulators of two-component regulatory systems (e.g., ArcB and PhoQ). The DNA-binding protein Dps that is generally regarded as cytoplasmic was significantly enriched in the outer membrane for all growth conditions examined, suggestive of moonlighting activities. These observations imply the existence of unknown transport mechanisms and novel functions for a subset of Salmonella proteins. Overall, this work provides a catalog of experimentally verified subcellular protein locations for Salmonella and a framework for further investigations using computational modeling.
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Registered trials
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