Evidence map›Paper›PMID 22900128›Full record

ArticleOxidative medicine and cellular longevity2012

Anti-inflammatory effects of a polyphenols-rich extract from tea (Camellia sinensis) flowers in acute and chronic mice models.

Bang-Tian Chen, Wei-Xi Li, Rong-Rong He, Yi-Fang Li, Bun Tsoi, Yu-Jia Zhai, Hiroshi Kurihara

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. Wound Healing and the Use of Medicinal Plants.Evidence-based complementary and alternative medicine : eCAM · 2019
    Review
  15. Article
  16. Role of Polyphenols and Other Phytochemicals on Molecular Signaling.Oxidative medicine and cellular longevity · 2015
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bang-Tian ChenInstitute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China.
Wei-Xi Li
Rong-Rong He
Yi-Fang Li
Bun Tsoi
Yu-Jia Zhai
Hiroshi Kurihara

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While beneficial health properties of tea leaves have been extensively studied, less attention is paid to the flowers of tea. In this study, the anti-inflammatory effects of hot water extract of tea (Camellia sinensis) flowers were investigated. Pharmacological studies found that administration of tea flowers extract (TFE) could effectively inhibit croton oil-induced ear edema and carrageenin-induced paw edema. Furthermore, administration of TFE also protected against Propionibacterium acnes (P. ances) plus lipopolysaccharide-(LPS-) induced liver inflammation by reversing the histologic damage and plasma alanine aminotransferase (ALT) increase. Moreover, the levels of nitric oxide (NO), tumor necrosis factor-(TNF)-α and interleukin-(IL-) 1β mRNA in mouse liver were markedly suppressed after treatment with TFE in mice with immunological liver inflammation. These results indicated that tea flowers had potent anti-inflammatory effects on acute and immunological inflammation in vivo, and may be used as a functional natural food.

Indexed as

Acute DiseaseAlanine TransaminaseAnimalsAnti-Inflammatory AgentsCamellia sinensisCapillary PermeabilityCarrageenanChronic DiseaseCroton OilDisease Models, AnimalEarEdemaExtremitiesFlowersInflammationInterleukin-1betaAlanine TransaminaseAnti-Inflammatory AgentsCarrageenanCroton OilInterleukin-1betaLipopolysaccharidesNitric OxidePlant ExtractsPolyphenolsRNA, MessengerTeaTumor Necrosis Factor-alpha

Identifiers

PMID22900128
PMCPMC3413976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.