ArticlePloS one2012
Shared "core" areas between the pain and other task-related networks.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Effect of acupuncture on brain regions modulation of mild cognitive impairment: A meta-analysis of functional magnetic resonance imaging studies.Frontiers in aging neuroscience · 2022Pooled it
- Effects of Chronic Pain Treatment on Altered Functional and Metabolic Activities in the Brain: A Systematic Review and Meta-Analysis of Functional Neuroimaging Studies.Frontiers in neuroscience · 2021Pooled it
- Gray matter alterations in chronic pain: A network-oriented meta-analytic approach.NeuroImage. Clinical · 2014Pooled it
- Trial
- Lower resting-state functional connectivity between frontoparietal and sensory networks is associated with recent pain intensity in a community sample of youth.Neuroimage. Reports · 2026Article
- Article
- Mimicking opioid analgesia in cortical pain circuits.bioRxiv : the preprint server for biology · 2025Article
- Representational maps in the brain: concepts, approaches, and applications.Frontiers in cellular neuroscience · 2024Review
- Processing of sensory, painful and vestibular stimuli in the thalamus.Brain structure & function · 2023Article
- Prediction and action in cortical pain processing.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Abnormalities of Thalamic Functional Connectivity in Patients with Migraine: A Resting-State fMRI Study.Pain and therapy · 2022Article
- Physical, Emotional, and Social Pain During COVID-19 Pandemic-Related Social Isolation.Trends in psychology · 2022Article
- Interhemispheric co-alteration of brain homotopic regions.Brain structure & function · 2021Article
- A lateralized model of the pain-depression dyad.Neuroscience and biobehavioral reviews · 2021Review
- BACON: A tool for reverse inference in brain activation and alteration.Human brain mapping · 2021Article
- The alteration landscape of the cerebral cortex.NeuroImage · 2019Article
- Association between migraine frequency and neural response to emotional faces: An fMRI study.NeuroImage. Clinical · 2019Article
- Differential Influence of Acupuncture Somatosensory and Cognitive/Affective Components on Functional Brain Connectivity and Pain Reduction During Low Back Pain State.Frontiers in neuroscience · 2019Article
- Brain structural alterations are distributed following functional, anatomic and genetic connectivity.Brain : a journal of neurology · 2018Article
- Neuroimaging of Pain: Human Evidence and Clinical Relevance of Central Nervous System Processes and Modulation.Anesthesiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The idea of a 'pain matrix' specifically devoted to the processing of nociceptive inputs has been challenged. Alternative views now propose that the activity of the primary and secondary somatosensory cortices (SI, SII), the insula and cingulate cortex may be related to a basic defensive system through which significant potentially dangerous events for the body's integrity are detected. By reviewing the role of the SI, SII, the cingulate and the insular cortices in the perception of nociceptive and tactile stimuli, in attentional, emotional and reward tasks, and in interoception and memory, we found that all these task-related networks overlap in the dorsal anterior cingulate cortex, the anterior insula and the dorsal medial thalamus. A thorough analysis revealed that the 'pain-related' network shares important functional similarities with both somatomotor-somatosensory networks and emotional-interoceptive ones. We suggest that these shared areas constitute the central part of an adaptive control system involved in the processing and integration of salient information coming both from external and internal sources. These areas are activated in almost all fMRI tasks and have been indicated to play a pivotal role in switching between externally directed and internally directed brain networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.