ArticleAdvances in hematology2012
Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model.
Article in Advances in hematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Multifactorial assessment of neutrophil chemotaxis efficiency from a drop of blood.Journal of leukocyte biology · 2022Article
- Signal integration in forward and reverse neutrophil migration: Fundamentals and emerging mechanisms.Current opinion in cell biology · 2021Review
- Hif-1alpha stabilisation is protective against infection in zebrafish comorbid models.The FEBS journal · 2020Article
- Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast.PLoS pathogens · 2020Article
- Live Imaging of Heart Injury in Larval Zebrafish Reveals a Multi-Stage Model of Neutrophil and Macrophage Migration.Frontiers in cell and developmental biology · 2020Article
- Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish.Nature communications · 2019Article
- PGEScience advances · 2018Article
- A Haptotaxis Assay for Neutrophils using Optical Patterning and a High-content Approach.Scientific reports · 2017Article
- Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics.Journal of leukocyte biology · 2016Review
- Article
- Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen.Disease models & mechanisms · 2016Article
- Neutrophil migration in infection and wound repair: going forward in reverse.Nature reviews. Immunology · 2016Review
- Metastasized lung cancer suppression by Morinda citrifolia (Noni) leaf compared to Erlotinib via anti-inflammatory, endogenous antioxidant responses and apoptotic gene activation.Molecular and cellular biochemistry · 2016Article
- Defining the phenotype of neutrophils following reverse migration in zebrafish.Journal of leukocyte biology · 2015Article
- Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models.Disease models & mechanisms · 2015Review
- Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration.The Journal of cell biology · 2014Article
- A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.Science translational medicine · 2014Article
- Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels.Integrative biology : quantitative biosciences from nano to macro · 2014Article
- Cxcl8 (IL-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modelling.Journal of the Royal Society, Interface · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Neutrophils must be removed from inflammatory sites for inflammation to resolve. Recent work in zebrafish has shown neutrophils can migrate away from inflammatory sites, as well as die in situ. The signals regulating the process of reverse migration are of considerable interest, but remain unknown. We wished to study the behaviour of neutrophils during reverse migration, to see whether they moved away from inflamed sites in a directed fashion in the same way as they are recruited or whether the inherent random component of their migration was enough to account for this behaviour. Using neutrophil-driven photoconvertible Kaede protein in transgenic zebrafish larvae, we were able to specifically label neutrophils at an inflammatory site generated by tailfin transection. The locations of these neutrophils over time were observed and fitted using regression methods with two separate models: pure-diffusion and drift-diffusion equations. While a model hypothesis test (the F-test) suggested that the datapoints could be fitted by the drift-diffusion model, implying a fugetaxis process, dynamic simulation of the models suggested that migration of neutrophils away from a wound is better described by a zero-drift, "diffusion" process. This has implications for understanding the mechanisms of reverse migration and, by extension, neutrophil retention at inflammatory sites.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.