ArticleDevelopment (Cambridge, England)2012
miR-92b regulates Mef2 levels through a negative-feedback circuit during Drosophila muscle development.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Temporal miRNA Biomarkers for Pupal Age Estimation inInsects · 2025Article
- High-throughput microRNA sequencing in the developing branchial arches suggests miR-92b-3p regulation of a cardiovascular gene network.Frontiers in genetics · 2025Article
- MicroRNA Targets PAP1 to Mediate Melanization inInternational journal of molecular sciences · 2024Article
- A Compilation of the Diverse miRNA Functions inInternational journal of molecular sciences · 2023Review
- Article
- The Genomic Architecture of Adaptation to Larval Malnutrition Points to a Trade-off with Adult Starvation Resistance in Drosophila.Molecular biology and evolution · 2021Article
- Foxo1-induced miR-92b down-regulation promotes blood-brain barrier damage after ischaemic stroke by targeting NOX4.Journal of cellular and molecular medicine · 2021Article
- MiR-92 Family Members Form a Cluster Required for Notochord Tubulogenesis in UrochordateGenes · 2021Article
- Article
- MiR-92b-3p inhibits proliferation and migration of C2C12 cells.Cell cycle (Georgetown, Tex.) · 2020Article
- Review
- microRNA 92b-3p regulates primordial follicle assembly by targeting TSC1 in neonatal mouse ovaries.Cell cycle (Georgetown, Tex.) · 2019Article
- Placental epigenetics for evaluation of fetal congenital heart defects: Ventricular Septal Defect (VSD).PloS one · 2019Article
- Proteomic and microRNA Transcriptome Analysis revealed the microRNA-SmyD1 network regulation in Skeletal Muscle Fibers performance of Chinese perch.Scientific reports · 2017Article
- Targeting myocyte-specific enhancer factor 2D contributes to the suppression of cardiac hypertrophic growth by miR-92b-3p in mice.Oncotarget · 2017Article
- Identification of microRNAs and their response to the stress of plant allelochemicals in Aphis gossypii (Hemiptera: Aphididae).BMC molecular biology · 2017Article
- E2F1-miR-20a-5p/20b-5p auto-regulatory feedback loop involved in myoblast proliferation and differentiation.Scientific reports · 2016Article
- Wnt4 is required for ostia development in the Drosophila heart.Developmental biology · 2016Article
- Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation.Basic research in cardiology · 2016Article
- Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mef2 is the key transcription factor for muscle development and differentiation in Drosophila. It activates hundreds of downstream target genes, including itself. Precise control of Mef2 levels is essential for muscle development as different Mef2 protein levels activate distinct sets of muscle genes, but how this is achieved remains unclear. Here, we have identified a novel heart- and muscle-specific microRNA, miR-92b, which is activated by Mef2 and subsequently downregulates Mef2 through binding to its 3'UTR, forming a negative regulatory circuit that fine-tunes the level of Mef2. Deletion of miR-92b caused abnormally high Mef2 expression, leading to muscle defects and lethality. Blocking miR-92b function using microRNA sponge techniques also increased Mef2 levels and caused muscle defects similar to those seen with the miR-92b deletion. Additionally, overexpression of miR-92b reduced Mef2 levels and caused muscle defects similar to those seen in Mef2 RNAi, and Mef2 overexpression led to reversal of these defects. Our results suggest that the negative feedback circuit between miR-92b and Mef2 efficiently maintains the stable expression of both components that is required for homeostasis during Drosophila muscle development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.