ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2012
A quantitative analysis of electrolyte exchange in the salivary duct.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- The elusive cephalic phase insulin response: triggers, mechanisms, and functions.Physiological reviews · 2023Review
- A Mathematical Model of Salivary Gland Duct Cells.Bulletin of mathematical biology · 2022Article
- Salivary biochemical variables in liver transplanted children and young adults.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Article
- Chemodynamic features of nanoparticles: Application to understanding the dynamic life cycle of SARS-CoV-2 in aerosols and aqueous biointerfacial zones.Advances in colloid and interface science · 2021Review
- Calcium Dynamics and Water Transport in Salivary Acinar Cells.Bulletin of mathematical biology · 2021Review
- Saliva for assessing creatinine, uric acid, and potassium in nephropathic patients.BMC nephrology · 2019Observational
- Mistargeting of a truncated Na-K-2Cl cotransporter in epithelial cells.American journal of physiology. Cell physiology · 2018Article
- Computational modeling of epithelial fluid and ion transport in the parotid duct after transfection of human aquaporin-1.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- RNA-seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation.BMC genomics · 2016Article
- Ae4 (Slc4a9) is an electroneutral monovalent cation-dependent Cl-/HCO3- exchanger.The Journal of general physiology · 2016Article
- Multiscale modelling of saliva secretion.Mathematical biosciences · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
A healthy salivary gland secretes saliva in two stages. First, acinar cells generate primary saliva, a plasma-like, isotonic fluid high in Na(+) and Cl(-). In the second stage, the ducts exchange Na(+) and Cl(-) for K(+) and HCO(3)(-), producing a hypotonic final saliva with no apparent loss in volume. We have developed a tool that aims to understand how the ducts achieve this electrolyte exchange while maintaining the same volume. This tool is part of a larger multiscale model of the salivary gland and can be used at the duct or gland level to investigate the effects of genetic and chemical alterations. In this study, we construct a radially symmetric mathematical model of the mouse salivary gland duct, representing the lumen, the cell, and the interstitium. For a given flow and primary saliva composition, we predict the potential differences and the luminal and cytosolic concentrations along a duct. Our model accounts well for experimental data obtained in wild-type animals as well as knockouts and chemical inhibitors. Additionally, the luminal membrane potential of the duct cells is predicted to be very depolarized compared with acinar cells. We investigate the effects of an electrogenic vs. electroneutral anion exchanger in the luminal membrane on concentration and the potential difference across the luminal membrane as well as how impairing the cystic fibrosis transmembrane conductance regulator channel affects other ion transporting mechanisms. Our model suggests the electrogenicity of the anion exchanger has little effect in the submandibular duct.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.