ArticleMolecular & cellular proteomics : MCP2012
Proteomics and deep sequencing comparison of seasonally active venom glands in the platypus reveals novel venom peptides and distinct expression profiles.
Article in Molecular & cellular proteomics : MCP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Insights into platypus crural gland transcriptomics - venom and beyond.BMC genomics · 2025Article
- Towards the Exploration and Evolution of Insulin-like Venoms in Actiniaria (Marine drugs · 2024Review
- Venom-derived peptides for breaking through the glass ceiling of drug development.Frontiers in chemistry · 2024Review
- Molecular Mechanisms of Animal Toxins, Venoms and Antivenoms.International journal of molecular sciences · 2023Article
- Article
- Review
- An integrated transcriptomic and proteomic approach to identify the main Torymus sinensis venom components.Scientific reports · 2021Article
- Review
- It Takes Two: Dimerization Is Essential for the Broad-Spectrum Predatory and Defensive Activities of the Venom Peptide Mp1a from the Jack Jumper AntBiomedicines · 2020Article
- The platypus: evolutionary history, biology, and an uncertain future.Journal of mammalogy · 2019Article
- Article
- The assassin bug Pristhesancus plagipennis produces two distinct venoms in separate gland lumens.Nature communications · 2018Article
- Are Fireworms Venomous? Evidence for the Convergent Evolution of Toxin Homologs in Three Species of Fireworms (Annelida, Amphinomidae).Genome biology and evolution · 2018Article
- Melt With This Kiss: Paralyzing and Liquefying Venom of The Assassin BugMolecular & cellular proteomics : MCP · 2017Article
- Review
- A Spur to Atavism: Placing Platypus Poison.Journal of the history of biology · 2015Article
- Why do we study animal toxins?Dong wu xue yan jiu = Zoological research · 2015Review
- Cabinet of Curiosities: Venom Systems and Their Ecological Function in Mammals, with a Focus on Primates.Toxins · 2015Review
- Review
- Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The platypus is a venomous monotreme. Male platypuses possess a spur on their hind legs that is connected to glands in the pelvic region. They produce venom only during the breeding season, presumably to fight off conspecifics. We have taken advantage of this unique seasonal production of venom to compare the transcriptomes of in- and out-of-season venom glands, in conjunction with proteomic analysis, to identify previously undiscovered venom genes. Comparison of the venom glands revealed distinct gene expression profiles that are consistent with changes in venom gland morphology and venom volumes in and out of the breeding season. Venom proteins were identified through shot-gun sequenced venom proteomes of three animals using RNA-seq-derived transcripts for peptide-spectral matching. 5,157 genes were expressed in the venom glands, 1,821 genes were up-regulated in the in-season gland, and 10 proteins were identified in the venom. New classes of platypus-venom proteins identified included antimicrobials, amide oxidase, serpin protease inhibitor, proteins associated with the mammalian stress response pathway, cytokines, and other immune molecules. Five putative toxins have only been identified in platypus venom: growth differentiation factor 15, nucleobindin-2, CD55, a CXC-chemokine, and corticotropin-releasing factor-binding protein. These novel venom proteins have potential biomedical and therapeutic applications and provide insights into venom evolution.
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